7367-87-5

Basic information

• Product Name: methyl 3-hydroxyoctanoate
• Synonyms: 3-Hydroxycaprylic acid methyl ester;3-Hydroxyoctanoic acid methyl ester
• CAS NO: 7367-87-5
• Molecular Formula: C₉H₁₈O₃
• Molecular Weight: 174.24
• EINECS: 230-917-3
• Product Categories: Aliphatics;Miscellaneous Reagents;Aliphatics, Miscellaneous Reagents
• Mol File: 7367-87-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 259.9 °C at 760 mmHg
• Flash Point: 102.2 °C
• Appearance: /
• Density: 0.976 g/cm³
• Vapor Pressure: 0.00184mmHg at 25°C
• Refractive Index: 1.439
• PKA: 14.09±0.20(Predicted)
• CAS DataBase Reference: methyl 3-hydroxyoctanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxyoctanoate(7367-87-5)
• EPA Substance Registry System: methyl 3-hydroxyoctanoate(7367-87-5)

Safety Data

• Hazardous Substances Data: 7367-87-5(Hazardous Substances Data)

Usage

Uses

3-Hydroxyoctanoic Acid Methyl Ester is a volatile ester found in fruit juices used as a flavoring compound.

InChI:InChI=1/C9H18O3/c1-3-4-5-6-8(10)7-9(11)12-2/h8,10H,3-7H2,1-2H3

Upstream product

• 132377-77-6 (2R*,3R*)-methyl 2-bromo-3-hydroxyoctanoate 
• 1038622-41-1 4-hydroxy-2-nonanone 
• 102368-24-1 (S)-4-hydroxyl-2-nonenone 
• 142-61-0 Hexanoyl chloride 
• 33796-86-0 3-hydroxyoctanoic acid 
• 485-80-3 S-adenosyl-L-methionine 
• 22348-95-4 methyl 3-oxooctanoate 
• 67-56-1 methanol 
• 10488-95-6 ethyl 3-oxooctanoate 
• 132377-81-2 (2S*,3R*)-methyl 2,3-dihydroxyoctanoate 
• 79-20-9 acetic acid methyl ester 
• 66-25-1 hexanal 
• 96-32-2 bromoacetic acid methyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 33796-86-0 3-hydroxyoctanoic acid 
• 22348-95-4 methyl 3-oxooctanoate 
• 7367-81-9 methyl (E)-oct-2-enoate 
• 66997-64-6 (S)-methyl 3-hydroxyoctanoate 
• 78672-90-9 methyl (R)-(-)-3-hydroxydecanoate 
• 35234-21-0 methyl 3-(acetoxy)octanoate 

Relevant articles and documents

Fungal metabolism of trans 2 octenoic acid

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Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds

A library of 18 different compounds was synthesized starting from (R)-3-hydroxyoctanoic acid which is derived from the bacterial polymer polyhydroxyalkanoate (PHA). Ten derivatives, including halo and unsaturated methyl and benzyl esters, were synthesized and characterized for the first time. Given that (R)-3-hydroxyalkanoic acids are known to have biological activity, the new compounds were evaluated for antimicrobial activity and in vitro antiproliferative effect with mammalian cell lines. The presence of the carboxylic group was essential for the antimicrobial activity, with minimal inhibitory concentrations against a panel of bacteria (Gram-positive and Gram-negative) and fungi (Candida albicans and Microsporum gypseum) in the range 2.87.0 mM and 0.16.3 mM, respectively. 3-Halogenated octanoic acids exhibited the ability to inhibit C. albicans hyphae formation. In addition, (R)-3-hydroxyoctanoic and (E)-oct-2-enoic acids inhibited quorum sensing-regulated pyocyanin production in the opportunistic pathogen Pseudomonas aeruginosa PAO1. Generally, derivatives did not inhibit mammalian cell proliferation even at 3-mM concentrations, while only (E)-oct-2-enoic and 3-oxooctanoic acid had IC50 values of 1.7 and 1.6 mM with the human lung fibroblast cell line.

Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase

Streptomyces coelicolor produces fatty acids for both primary metabolism and for biosynthesis of the secondary metabolite undecylprodiginine. The first and last reductive steps during the chain elongation cycle of fatty acid biosynthesis are catalyzed by FabG and FabI. The S. coelicolor genome sequence has one fabI gene (SCO1814) and three likely fabG genes (SCO1815, SCO1345, and SCO1846). We report the expression, purification, and characterization of the corresponding gene products. Kinetic analyses revealed that all three FabGs and FabI are capable of utilizing both straight and branched-chain β-ketoacyl-NAC and enoyl-NAC substrates, respectively. Furthermore, only SCO1345 differentiates between ACPs from both biosynthetic pathways. The data presented provide the first experimental evidence that SCO1815, SCO1346, and SCO1814 have the catalytic capability to process intermediates in both fatty acid and undecylprodiginine biosynthesis.