10237-77-1Relevant articles and documents
Abnormal metabolites of isoleucine in a patient with propionyl-CoA carboxylase deficiency
Sweetman,Weyler,Nyhan,de Cespedes,Loria,Estrada
, p. 198 - 207 (1978)
A number of previously unrecognized abnormal metabolites have been identified and quantitated in the urine of a patient with an inherited deficiency of propionyl CoA carboxylase. These included the isoleucine metabolites 2 methyl 3 hydroxybutyric acid and 2 methylacetoacetic acid. The isomers 3 hydroxyvaleric acid and 3 oxovaleric acid were found, which may be products of the condensation of propionyl CoA with acetyl CoA catalyzed by 3 oxoacyl CoA thiolases. Following a load of isoleucine, 2 methylbutyrylglycine was identified. This metabolite has not previously been observed in man.
Ives,Kerlogue
, p. 1362 (1940)
A study of the reaction of n-BuLi with Ti(Oi-Pr)4 as a method to generate titanacyclopropane and titanacyclopropene species
Rassadin, Valentin A.,Six, Yvan
, p. 787 - 794 (2014/01/23)
The use of the combination of reagents Ti(Oi-Pr)4/n-BuLi, introduced by the group of J.J. Eisch in 2001, has only found a few applications so far, with sometimes conflicting observations. This article describes a study aimed at clarifying the nature, the stability and the reactivity of the active organometallic species involved. Reactions with CO2 and other trapping reagents reveal that it is generated within a few minutes at 0 C in THF, where it can be considered to be stable for 30 min. Most of our results are consistent with the expected titanacyclopropane nature of this reagent but some observations suggest that the chemistry at play may be more complicated.
Process for production of N-acyl-α-amino acids
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, (2008/06/13)
A process for the production of an N-acyl-α-amino acid represented by the general formula STR1 wherein R1, R2, R3 and R4, independently from each other, represent a hydrogen atom, an alkyl or cycloalkyl group which may be substituted, or an aryl or heteroaromatic group selected from the group consisting of furyl, pyrrolyl, pyridinyl, thienyl and indolyl which may be substituted, which comprises reacting an oxirane represented by the general formula STR2 wherein R1 and R2 are as defined above, an amide compound represented by the general formula wherein R3 and R4 are as defined above, and carbon monoxide in the presence of hydrogen, a cobalt-containing catalyst, and a promoter composed of a compound containing a metal selected from Groups I, II, III and IV of the periodic table.
