102397-26-2Relevant academic research and scientific papers
Synthesis of 3-Aryl-2-pyrones by Palladium-Catalyzed Cross-Coupling of Aryl Iodides with Cyclic Vinyldiazo Ester
Huang, Jun,Li, Linyong,Chen, Haoguo,Xiao, Tiebo,He, Yuwei,Zhou, Lei
, p. 9204 - 9209 (2017/09/11)
A palladium-catalyzed cross-coupling reaction of aryl iodides with cyclic vinyldiazo ester was developed. The reaction provides various 3-aryl-2-pyrones in good yields with high functional group tolerance. The synthetic application of the resulting 3-aryl-2-pyrones as the diene component in a Diels-Alder reaction was also described.
A concise access to 3-substituted 2-pyrones
Frebault, Frederic,Oliveira, Maria Teresa,Woestefeld, Eckhard,Maulide, Nuno
supporting information; experimental part, p. 7962 - 7965 (2011/02/22)
The development of a modular synthesis of 3-substituted-2-pyrones is described. The attainment of this strategy hinges on a new electrophilic pyrone derivative which can be readily prepared on a multigram scale and which performs very competently in metal-catalyzed cross-coupling reactions with a variety of nucleophiles.
A convenient synthesis of 3-aryl-δ-lactones
Rosen, Jonathan D.,Nelson, Todd D.,Huffman, Mark A.,McNamara, James M.
, p. 365 - 368 (2007/10/03)
Various (±)-3-aryl-δ-lactones have been prepared from the corresponding arylacetic acids. The lithium dianion of the acid is alkylated with 1-bromo-3-chloropropane and the unpurified product is cyclized with DBU in typically ca. 80% yield over both steps.
Structure-Activity Study of 6-Substituted 2-Pyranones as Inactivators of α-Chymotrypsin
Boulanger, William A.,Katzenellenbogen, John A.
, p. 1159 - 1163 (2007/10/02)
A series of 2-pyranones, bearing halogens or electron-withdrawing groups at the 6-position and alkyl, aryl, or aralkyl groups at positions 3, 4, and 5, were synthesized to investigate their binding to and inactivation of chymotrypsin.Both binding and inac
