102469-23-8

Upstream product

• 913257-10-0 3-(iodomethyl)-2,3-diphenylisoindolin-1-one 
• 913257-04-2 N-phenyl-2-(1-phenylethen-1-yl)benzamide 
• 201230-82-2 carbon monoxide 
• 7788-51-4 N-(1,1-diphenyl-ethyl)-aniline 
• 103-71-9 phenyl isocyanate 
• 24892-82-8 1-bromo-2-(1-phenylpropen-1-yl)benzene 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

Synthesis of 3,3-disubstituted isoindolin-1-ones via iodoamination of α-substituted secondary 2-vinylbenzamides

A new and simple method for the preparation of 3,3-disubstituted isoindolin-1-ones from α-substituted 2-bromostyrenes is described. Construction of the isoindolin-1-one skeleton was accomplished by treating α-substituted secondary 2-vinylbenzamides, easil