24892-82-8

Upstream product

• 917-64-6 methyl magnesium iodide 
• 13047-06-8 o-bromobenzophenone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 88-65-3 2-bromobenzoic-acid 
• 583-55-1 1-Bromo-2-iodobenzene 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 82645-13-4 1-(2-bromophenyl)-1-phenylethan-1-ol 
• 2142-69-0 2-bromophenyl methyl ketone 
• 591-17-3 meta-bromotoluene 
• 100-58-3 phenylmagnesium bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 20667-19-0 methyltriphenylphosphonium iodide 
• 2065-66-9 methyl-triphenylphosphonium iodide 

Downstream Products

• 942512-20-1 N-ethyl-2-(1-phenylethenyl)thiobenzamide 
• 942512-21-2 N-cyclohexyl-2-(1-phenylethenyl)thiobenzamide 
• 942512-18-7 N-(3-methylphenyl)-2-(1-phenylethenyl)thiobenzamide 
• 942512-19-8 N-(4-bromophenyl)-2-(1-phenylethenyl)thiobenzamide 
• 913257-06-4 N-(n-butyl)-2-(1-phenylethenyl)benzamide 
• 913257-07-5 N-tert-butyl-2-(1-phenylethenyl)benzamide 
• 913257-04-2 N-phenyl-2-(1-phenylethen-1-yl)benzamide 
• 913257-10-0 3-(iodomethyl)-2,3-diphenylisoindolin-1-one 
• 913257-11-1 2-(4-chlorophenyl)-3-iodomethyl-3-phenylisoindolin-1-one 
• 913257-12-2 2-(n-butyl)-3-iodomethyl-3-phenylisoindolin-1-one 
• 913257-13-3 2-tert-butyl-3-iodomethyl-3-phenylisoindolin-1-one 
• 102469-23-8 3-methyl-2,3-diphenylisoindolin-1-one 
• 906091-57-4 3-phenyl-3-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanone 
• 1020726-45-7 1-[2-(2-phenylethenyl)phenyl]cyclohexanol 

Relevant academic research and scientific papers

Stereocontrolled synthesis of carbon-carbon double bond locked analogues of strobilurins which are characterized by a trans-1,2-disubstituted cyclopropane ring

The racemic forms of four new carbon-carbon double bond locked analogues of strobilurins, which are characterized by a trans-1,2-disubstituted cyclopropane ring, have been synthesized according to a strategy which involves palladium-catalyzed cross-coupli

Asymmetric Halocyclizations of 2-Vinylbenzyl Alcohols with Chiral FLPs

By the use of a chiral frustrated Lewis pair (FLP) consisting of a chiral-diene-derived borane and tBu3P as the catalyst, an asymmetric halocyclization of 2-vinylbenzyl alcohols with NBS or NIS was successfully realized. A variety of optically active 1,3-dihydroisobenofuran derivatives were obtained in high yields with up to 87% ee and could be conveniently converted to other useful chiral compounds.

Enantioselective synthesis of 1-aminoindene derivativesviaasymmetric Br?nsted acid catalysis

We describe a catalytic asymmetric iminium ion cyclization reaction of simple 2-alkenylbenzaldimines using a BINOL-derived chiralN-triflyl phosphoramide. The corresponding 1-aminoindenes and tetracyclic 1-aminoindanes are formed in good yields and high enantioselectivities. Further, the chemical utility of the obtained enantiopure 1-aminoindene is demonstrated for the asymmetric synthesis of (S)-rasagiline.

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

Preparation method of silicon spiro compound (by machine translation)

The invention discloses a preparation method of a silicon spiro compound. The invention provides a preparation method of a silicon spiro compound as shown in a formula II, which comprises the following steps: in a solvent, a compound represented by the formula III is subjected to cyclization reaction under the presence of a monovalent rhodium catalyst and a phosphine ligand to obtain the silicon spiro compound as shown in the formula II. The preparation method of the silicon spiro compound can be simple. , The establishment of the silicon spiro compound is realized conveniently and efficiently. (by machine translation)

Cu/Ni-Catalyzed Cyanomethylation of Alkenes with Acetonitrile for the Synthesis of β,γ-Unsaturated Nitriles

We have developed a protocol for the Cu/Ni-catalyzed cyanomethylation of alkenes with acetonitrile for the synthesis of β,γ-unsaturated nitriles. This is the first example of a direct coupling of the alkene sp2 C - H bond and the acetonitrile sp3 C - H bond for the preparation of β,γ-unsaturated nitriles. Acetonitrile, an inexpensive and stable solvent, is demonstrated to be a useful cyanomethyl source. The combination of copper and nickel catalysts resulted in a high reaction efficiency.

The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides

A cascade alkene sulfonylation that simultaneously forges C-S and C-C bonds is a highly efficient and powerful approach for directly accessing structurally diverse sulfonylated compounds in a single operation. The reaction was enabled by visible-light-mediated regioselective radical addition of sulfonyl chlorides to 2-arylstyrenes using fac[Ir(ppy)3] as a photocatalyst, demonstrating its unique role in a photocascade process to execute atom transfer radical addition (ATRA) followed by photocyclization. A new class of sulfonyl-substituted fluorenes and pyrroloindoles, which are useful in the field of photoelectronic materials and medicinal chemistry, was produced in excellent yields by this photocascade reaction. In contrast, the cyclization was interrupted when using the [Ru(bpy)3Cl2] catalyst having lower reduction potential, leading only to the formation of a C-S bond and the production of acyclic sulfonylated 2-arylstyrenes under identical reaction conditions. The synthetic utility of the present room-temperature photocatalysis is enhanced by the broad availability of bench-stable sulfonyl chlorides and unactivated olefins, thereby providing a cost-effective and broad-scope protocol.

Reactivity of Carbenes in Aqueous Nanomicelles Containing Palladium Nanoparticles

Palladium nanoparticles ligated with inexpensive triphenylphosphine and amphiphile PS-750-M are suitable for exploring the reactivity of carbenes in aqueous nanomicelles. Nanocatalyst is highly selective for metal-carbene migratory insertion, and micelle

Pd-Catalyzed Enantioselective Ring Opening/Cross-Coupling and Cyclopropanation of Cyclobutanones

A palladium-catalyzed enantioselective sequential ring-opening/cross-coupling of cyclobutanones is disclosed that provides chiral indanones bearing C3-quaternary stereocenters. The reaction process involves palladium-catalyzed nucleophilic addition of cyc

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.