102486-62-4Relevant academic research and scientific papers
In situ Generation and Utilization of CO: An Efficient Route towards N-Substituted Saccharin via Carbonylative Cyclization of 2-Iodosulfonamides
Chavan, Sujit P.,Adithyaraj,Bhanage, Bhalchandra M.
supporting information, p. 2000 - 2003 (2017/09/13)
The present protocol demonstrates the synthesis of N-substituted saccharines via carbonylative cyclization of 2-iodosulfonamides using a Pd(OAc) 2 /Xantphos catalyst system and phenyl formate as a CO source. A variety of saccharin derivatives is synthesized under milder reaction conditions.
