102490-44-8

Upstream product

• 97747-51-8 (1R)-(-)-1,2,3-tri-O-acetyl-(1,3/2,4,6)-4-bromo-6-bromomethyl-1,2,3-cyclohexanetriol 
• 78963-40-3 2L-(2,4/3,5)-2,3,4,5-tetrahydroxycyclohexan-1-one 
• 488-76-6 (-)-viburnitol 
• 1350889-90-5 C₁₂H₁₄O₇ 
• 108-24-7 acetic anhydride 
• 796850-23-2 (1R,2R,3S)-6-Methylene-cyclohex-4-ene-1,2,3-triol 

Downstream Products

• 942065-91-0 C₁₅H₁₉BrO₈ 
• 177898-42-9 (1R,2S,3S,4R)-5-hydroxymethyl-1-octylamino-2,3,4-trihydroxycyclohex-5-ene 
• 796850-25-4 C₁₃H₁₆Br₂O₆ 
• 796850-24-3 C₁₃H₁₆Br₂O₆ 
• 148347-74-4 (1R,4S,5R,6S)-4,5,6-tri(benzyloxy)-1-C-(hydroxymethyl)cyclohex-2-en-1-ol 
• 148291-30-9 <(1S,2S,4S,5S,6R)-5-benzyloxy-8,8,2',2'-tetramethylspiro<7,9-dioxabicyclo<4.3.0>nonane-2,4'-1',3'-dioxolan>-4-yl>-<(5''R,6''S,7''S,8''S,9''R,10''S)-8'',9'',10''-tribenzyloxy-6''-hydroxy-2'',2''-dimethyl-1'',3''-dioxaspiro<4.5>decan-7''-yl>amine 
• 106988-97-0 (1'S,2'S,3'S,4'R,5'R,6'S)-3',4',5'-tribenzyloxy-2,2-dimethylspiro<1,3-dioxolane-4,2'-oxabicyclo<4.1.0>heptane> 
• 106988-95-8 1L-(1,2,4/3)-2,3,4-tri-O-benzyl-1-C-(hydroxymethyl)-1,7-O-isopropyliden-5-cyclohexen-1,2,3,4-tetrol 
• 106988-92-5 1L-(1,2,4/3)-2,3,4-tri-O-benzyl-1-C-(hydroxymethyl)-5-cyclohexen-1,2,3,4-tetrol 
• 85716-46-7 1D-(1,3/2)-1,2,3-tri-O-benzyl-4-methylene-5-cyclohexen-1,2,3-triol 
• 796850-23-2 (1R,2R,3S)-6-Methylene-cyclohex-4-ene-1,2,3-triol 
• 74024-02-5 tri-O-acetyl-(-)-deoxyvalidatol 

Relevant academic research and scientific papers

Transformation of quercitols into 4-methylenecyclohex-5-ene-1,2,3-triol derivatives, precursors for the chemical chaperones N-octyl-4-epi-β- valienamine (NOEV) and N-octyl-β-valienamine (NOV)

(+)-proto-Quercitol (1) and (-)-vibo-quercitol (2), both of which could be readily prepared by the bioconversion of myo-inositol, were successfully converted into the corresponding 4-methylenecyclohex-5-ene-1,2,3-triol derivatives. These compounds were demonstrated to be suitable precursors, preserving their configurations, for bioactive carba-aminosugars such as the potent chemical chaperone drug candidates, N-octyl-4-epi-β-valienamine (NOEV, 3) and N-octyl-β-valienamine (NOV, 4).

ACID ADDITION SALT OF CARBASUGAR AMINE DERIVATIVE

An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, an alkynyl group, an acyl group,

Synthesis and Trehalose-inhibitory Activity of an Imino-linked Dicarba-&α,&α-trehalose and Analogues thereof

Dicarba-α,α-trehalose 2a, bis-(5a-carba-α-D-glucopyranosyl)amine, was prepared by the coupling of di-O-isopropylidene-α-validamine 5 and protected carba-sugar epoxide 7, followed by removal of the 2'-hydroxy group and conventional deprotection.Likewise, i