148347-74-4

Upstream product

• 102490-44-8 Acetic acid (1R,2S,6R)-2,6-diacetoxy-5-methylene-cyclohex-3-enyl ester 
• 796850-23-2 (1R,2R,3S)-6-Methylene-cyclohex-4-ene-1,2,3-triol 
• 97747-51-8 (1R)-(-)-1,2,3-tri-O-acetyl-(1,3/2,4,6)-4-bromo-6-bromomethyl-1,2,3-cyclohexanetriol 
• 100-39-0 benzyl bromide 
• 754224-71-0 (1R,4S,5R,6S)-1-C-(acetoxymethyl)-4,5,6-tri(benzyloxy)cyclohex-2-en-1-ol 
• 85716-46-7 1D-(1,3/2)-1,2,3-tri-O-benzyl-4-methylene-5-cyclohexen-1,2,3-triol 

Downstream Products

• 754224-47-0 Phthalic acid 1-((1R,4S,5R,6S)-1-acetoxy-4,5,6-tris-benzyloxy-cyclohex-2-enylmethyl) ester 2-((2S,3R,4S,5R,6R)-3-azido-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester 

Relevant academic research and scientific papers

An investigation into the synthesis of some molecules related to methyl acarviosin

Methyl acarviosin is an impressive inhibitor of some glycoside hydrolases that process substrates containing α-D-glucosidic linkages. In an attempt to provide putative inhibitors for enzymes that process β-D-glucosidic linkages, we report an improved synthesis of a hydroxylated 'methyl β-acarviosin' and our efforts towards various deoxygenated versions of methyl β-acarviosin. As well, the synthesis of a 1,3-linked variant of methyl β-acarviosin is reported, together with an unsuccessful 'tether' approach to construct the crucial nitrogen linkage in the acarviosins.

Synthesis and Trehalose-inhibitory Activity of an Imino-linked Dicarba-&α,&α-trehalose and Analogues thereof

Dicarba-α,α-trehalose 2a, bis-(5a-carba-α-D-glucopyranosyl)amine, was prepared by the coupling of di-O-isopropylidene-α-validamine 5 and protected carba-sugar epoxide 7, followed by removal of the 2'-hydroxy group and conventional deprotection.Likewise, i