942065-91-0

Upstream product

• 127-08-2 potassium acetate 
• 78963-40-3 2L-(2,4/3,5)-2,3,4,5-tetrahydroxycyclohexan-1-one 
• 102490-44-8 Acetic acid (1R,2S,6R)-2,6-diacetoxy-5-methylene-cyclohex-3-enyl ester 
• 488-76-6 (-)-viburnitol 
• 127-09-3 sodium acetate 
• 1350889-90-5 C₁₂H₁₄O₇ 

Downstream Products

• 177898-42-9 (1R,2S,3S,4R)-5-hydroxymethyl-1-octylamino-2,3,4-trihydroxycyclohex-5-ene 
• 140148-01-2 C₁₅H₁₉N₃O₈ 
• 90025-03-9 (1S)-(1,3,6/2)-4-acetoxymethyl-1,2,3-tri-O-acetyl-6-azido-4-cyclohexene-1,2,3-triol 

Relevant academic research and scientific papers

Transformation of quercitols into 4-methylenecyclohex-5-ene-1,2,3-triol derivatives, precursors for the chemical chaperones N-octyl-4-epi-β- valienamine (NOEV) and N-octyl-β-valienamine (NOV)

(+)-proto-Quercitol (1) and (-)-vibo-quercitol (2), both of which could be readily prepared by the bioconversion of myo-inositol, were successfully converted into the corresponding 4-methylenecyclohex-5-ene-1,2,3-triol derivatives. These compounds were demonstrated to be suitable precursors, preserving their configurations, for bioactive carba-aminosugars such as the potent chemical chaperone drug candidates, N-octyl-4-epi-β-valienamine (NOEV, 3) and N-octyl-β-valienamine (NOV, 4).

ACID ADDITION SALT OF CARBASUGAR AMINE DERIVATIVE

An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, an alkynyl group, an acyl group,