102496-83-3

Upstream product

• 201230-82-2 carbon monoxide 
• 108-98-5 thiophenol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 556-82-1 3-methyl-2-buten-1-ol 
• 598-25-4 Dimethylallene 
• 115-18-4 2-methyl-3-buten-2-ol 
• 23534-96-5 1-chloro-2,2-dibromo-3,3-dimethylcyclopropane 
• 78-79-5 isoprene 
• 70908-42-8 α,α-dimethyl allyl methyl carbonate 

Relevant academic research and scientific papers

Highly regioselective thiocarbonylation of conjugated dienes via palladium-catalyzed three-component coupling reactions

Three-component coupling reaction of conjugated dienes, thiols, and carbon monoxide affords an atom-economical thiocarbonylation of the dienes to give β,γ-unsaturated thioesters as the sole products. A catalyst system based on [Pd(OAc)2] and Ph

Highly Regioselective Palladium-Catalyzed Thiocarbonylation of Allenes with Thiols and Carbon Monoxide

A series of mono- and di-substituted allenes underwent direct thiocarbonylation with thiols and carbon monoxide to form the corresponding β,γ-unsaturated thioesters in 73-94% yields. This reaction requires catalytic quantities of Pd(OAc)2 (3 mo

Highly Regioselective Thiocarbonylation of Allylic Alcohols with Thiols and Carbon Monoxide Catalyzed by Palladium Complexes: A New and Efficient Route to β,γ-Unsaturated Thioesters

The reaction of allylic alcohols with thiols and carbon monoxide in the presence of catalytic quantities of Pd(OAc)2 (3 mol %), triphenylphosphine (12 mol %), and p-TsOH (5 mol %) leads to a novel thiocarbonylation to afford β,γ-unsaturated thioesters in good to excellent yields. Other palladium catalyst systems such as Pd2(dba)3·CHCl3-PPh3-p-TsOH, Pd(PPh3)4-p-TsOH, and Pd(OAc)2-dppb-p-TsOH are also effective for this transformation. The thiocarbonylation reaction is believed to proceed via a allylpalladium intermediate. The reaction occurs highly regioselectively at the least hindered allylic terminal carbon of the substrate to give the products. This new carbonylation procedure was readily applied to a variety of allylic alcohols and both aromatic and aliphatic thiols.

SYNTHESIS OF Β,Γ-UNSATURATED CARBOXYLIC ACID DERIVATIVES BY THE NOVEL Ni(CO)4-INDUCED RING-OPENING CARBONYLATION REACTION OF 1,1-DIBROMO-2-CHLOROCYCLOPROPANES

1,1-Dibromo-2-chlorocyclopropanes underwent the Ni(CO)4-induced ring-opening carbonylation reaction with alcohol or amine giving the β,γ-unsaturated carboxylic acid and dicarboxylic acid derivatives.Use of N,N-dimethyltrimethylsilylamine as an initial nuc