102575-24-6 Usage
Definition
ChEBI: A benzodioxine that is idazoxan substituted at position 2 by a methoxy group.
Biological Activity
Potent, selective α 2 -adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α 2D over the α 2A subtypes (pK d values are 9.7 and 8.2 respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 102575-24-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,5,7 and 5 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 102575-24:
(8*1)+(7*0)+(6*2)+(5*5)+(4*7)+(3*5)+(2*2)+(1*4)=96
96 % 10 = 6
So 102575-24-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H
102575-24-6Relevant articles and documents
α-Adrenoreceptor Reagents. 3. Synthesis of Some 2-Substituted 1,4-Benzodioxans as Selective Presynaptic α2-Adrenoreceptor Antagonists
Stillings, Michael R.,Chapleo, Christopher B.,Butler, Richard C. M.,Davis, J. Alfred,England, C. David,et al.
, p. 1054 - 1062 (2007/10/02)
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective α2-adrenoreceptor antagonist idazoxan (RX 781094) is described.Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups in many cases gives compounds whose potencies and selectivities are significantly greater than those of the parent compound.
