102580-34-7

Upstream product

• 22158-78-7 2-chloro-N-(2',5'-dimethoxyphenyl)acetamide 
• 102-56-7 2,5-dimethoxyaniline 
• 20734-68-3 2-aminohydroquinone 
• 111-42-2 2,2'-iminobis[ethanol] 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 26021-57-8 3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine 
• 53412-38-7 6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one 

Relevant academic research and scientific papers

OXAZINE-BASED FLUOROPHORE COMPOUNDS FOR NERVE-SPECIFIC IMAGING

This invention concerns novel oxazine-based fluorophore compounds useful in invivo nerve imaging, as well as compositions comprising them and methods for their use.

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

ACTIVATIBLE DYES

Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.

Cyan dye-forming couplers and photographic elements and processes

Cyan dye-forming 6-hydroxy-2H-1,4-benzoxazin-3-(4H)-one couplers, preferably cyan dye-forming couplers corresponding to the general formula: STR1 wherein R represents hydrogen or R"'--X--NH, R' represents hydrogen or a substituted or unsubstituted alkyl group, R" represents hydrogen or Riv --X--, X represents a member selected from the group consisting of --CO--, --SO2 --, --OCOCO--, --NHCO--, R"' and Riv represent a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group and Y and Z, the same or different, represent hydrogen, halogen and a substituted or unsubstituted alkyl or alkoxy group, are described for use in silver halide color photographic processes and elements.