1025875-49-3

Upstream product

• 142626-70-8 4-(2-methylphenyl)-2-oxo-6,7,8,9-tetrahydro-2H-naphtho[2,3-b]pyran-3-carboxylic acid 
• 32337-86-3 1-bromo-5,6,7,8-tetrahydronaphthalen-2-ol 
• 93877-49-7 3-(2-methylbenzyl)-5,6,7,8-tetrahydro-2-naphthol 
• 933-88-0 ortho-toluoyl chloride 
• 142626-68-4 1-bromo-3-(2-methylbenzoyl)-5,6,7,8-tetrahydro-2-naphthol 
• 142626-67-3 2-benzyloxy-1-bromo-5,6,7,8-tetrahydronaphthalene 
• 142626-69-5 ethyl 4-(2-methylphenyl)-2-oxo-6,7,8,9-tetrahydro-2H-naphtho[2,3-b]pyran-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.