67822-79-1

Upstream product

• 67822-75-7 N-benzyl-1,3-dioxoisoindoline-5-carboxylic acid 
• 100-46-9 benzylamine 
• 1025907-99-6 2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid benzylamide 
• 552-30-7 trimellitic Anhydride 

Downstream Products

• 159718-63-5 2-benzyl-5-pentanoylisoindolin-1,3-dione 
• 1026257-68-0 2-benzyl-5-acetylisoindolin-1,3-dione 
• 1027511-63-2 2-Benzyl-5-ethyl-isoindole-1,3-dione 
• 159718-64-6 2-benzyl-5-pentyl-isoindolin-1,3-dione 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers

A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium c

Synthesis of isotopically-labelled nitroxyl radicals for use as spin probes

The synthesis of [15N]-1,1,3,3-tetrakis(trideuteriomethyl)isoindolin-2-yloxyl and of some 5-alkyl derivatives have been achieved by standard synthetic routes. The presence of deuterium improves the sharpness of the signals, and this, together with the incorporation of nitrogen-15, enhances the application of such compounds as spin probes; allyl substituents at C-5 improve the lipophilicity.