1026192-65-3

Upstream product

• 199177-26-9 3-bromo-5-hydroxybenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 13949-93-4 ethyl-2-formyl-1-cyclopropane carboxylate 
• 15224-11-0 trans-ethyl 2-hydroxymethyl-1-cyclopropanecarboxylate 
• 2432-12-4 2,6-dichloro-4-methylophenol 
• 1056555-28-2 ethyl 2-(((3-(((3-(tert-butoxycarbonyl)amino)-2-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzyl)propanoyl)(cyclopropyl)amino)methyl)-5-(3-methoxypropyl)phenoxy)methyl)cyclopropanecarboxylate 
• 1056555-22-6 tert-butyl (3-[[3-{[tert-butyl(dimethyl)silyl]oxy}-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate 
• 1056555-21-5 tert-butyl (3-[[3-hydroxy-5-(3-methoxypropyl)benzyl](cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate 
• 1056555-04-4 3-[(tert-butoxycarbonyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoic acid 
• 1056555-03-3 methyl 3-[(tert-butoxycarbonyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoate 
• 1056555-02-2 methyl (2E)-2-cyano-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}acrylate 
• 921630-48-0 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{3-methoxypropyl}benzyl)amino]cyclopropane 
• 1026786-89-9 [(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane 
• 921630-61-7 4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-benzaldehyde 

Relevant academic research and scientific papers

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.