1026239-89-3

Upstream product

• 152500-51-1 (1R,3R)-2,2,2-trichloroethyl 3-<(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate 
• 152500-45-3 (2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-<2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>acetyl>-3-methoxymethoxymethylpyrrolidine 
• 152500-47-5 3-<(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-8-methoxyisoquinoline 
• 152500-50-0 (1R,3R)-3-<(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 152500-41-9 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 152500-43-1 2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 152500-42-0 2-<(4S,5R)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole 
• 38197-43-2 2-bromo-3-methylanisole 
• 108-24-7 acetic anhydride 
• 152500-53-3 (1R,3R)-2,2,2-trichloroethyl 3-<(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl>-1-hydroxymethyl-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate 

Downstream Products

• 84573-33-1 (-)-quinocarcin 
• 96251-59-1 <5R-(5α,7β,8β,10β,11β,11aβ)>-7-cyano-5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-(hydroxymethyl)-13-methyl-8,11-iminoazepino<1,2-b>isoquinoline-10-carboxylic acid 

Relevant academic research and scientific papers

Synthetic Studies on Quinocarcin and Its Related Compounds. 4. Total Synthesis of Enantiomeric Pairs of Quinocarcin and 10-Decarboxyquinocarcin

The title synthesis was accomplished by featuring (i) aldol coupling of the 3-methylanisole 11 with 5-substituted- or 3,5-disubstituted- 2-formylpyrrolidine 4 or 5, (ii) highly diastereoselective reduction of 1,3-disubstituted isoquinolines 14 and 33 to c

Total Synthesis of (-)-Quinocarcin and (-)-10-Decarboxyquinocarcin

The title total synthesis was accomplished by employing diastereoselective reduction of 1,3-disubstituted isoquinolines as a key step.The cytotoxicity of 10-decarboxyquinocarcin and its 7-cyano congeners were found to be 10-1000 times more potent than tho