10264-16-1

Basic information

• Product Name: N-butylbutanamide
• Synonyms: butanamide, N-butyl-; N-Butylbutanamide
• CAS NO: 10264-16-1
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.2267
• Mol File: 10264-16-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 235.8°C at 760 mmHg
• Flash Point: 131°C
• Density: 0.86g/cm³
• Vapor Pressure: 0.0491mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: N-butylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butylbutanamide(10264-16-1)
• EPA Substance Registry System: N-butylbutanamide(10264-16-1)

Safety Data

• Hazardous Substances Data: 10264-16-1(Hazardous Substances Data)

Upstream product

• 999-33-7 N-chloro-N,N-dibutylamine 
• 108-24-7 acetic anhydride 
• 107-92-6 butyric acid 
• 107-10-8 propylamine 
• 109-73-9 N-butylamine 
• 141-75-3 butyryl chloride 
• 156-54-7 sodium butyrate 
• 3858-78-4 n-butylamine hydrochloride 
• 25307-01-1 p-tolylacetic acid sodium salt 
• 114-84-1 phenylpropionic acid sodium salt 
• 1984-06-1 sodium caprylate 
• 532-32-1 sodium benzoate 
• 541-35-5 butanamide 
• 2635-84-9 p-nitrophenyl butyrate 

Downstream Products

• 78455-93-3 N-butyl-N-nitroso-butyramide 
• 107515-71-9 Butyl-[3-ethyl-5-methyl-5-phenylselanylmethyl-dihydro-furan-(2E)-ylidene]-amine 
• 107515-92-4 4-Butylaminomethyl-2-methyl-1-phenylselanyl-hexan-2-ol 

Relevant articles and documents

The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl)ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present. The Royal Society of Chemistry.

PRODUCTION METHOD OF AMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a production method of an amide compound, which can use a variety of carboxylic acid halides and can produce a desired amide compound at a yield higher than a batch process by suppressing a side reaction. SOLUTION: Provided is a production method of an amide compound using a flow type reactor, in which the flow type reactor includes: a first flow path; a second flow path; a first mixing means provided at a confluent part of the first flow path and the second flow path; and a third flow path that is connected to the first mixing means and arranged on a down stream side of the first mixing means, the production method comprising: a mixing step of obtaining a mixed liquid by circulating a first liquid containing the carboxylic acid halide in the first flow path, circulating a second liquid containing an amine compound having a molecular weight of 1,000 or less, an inorganic alkali and water in the second flow path, and mixing the first liquid and the second liquid by the first mixing means to obtain a mixture; and a reaction step of obtaining an amide compound by circulating the mixed liquid in the third flow path and reacting the carboxylic acid halide and the amine compound in the third flow path. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPO&INPIT

PRODUCTION OF AMINES

A process for the hydrogenation of carboxylic acids and/or derivatives, particularly amides, is described. The process includes reacting an acid or derivative such as an amide with a source of hydrogen in the presence of a catalyst system. The catalyst system obtainable by combining: (a) a source of ruthenium, and (b) a phosphine compound of general Formula I: (Formula I). The hydrogenation reaction is carried out in the presence of a low concentration of water or at low pressure or in the presence of a source of ammonia or the hydrogenation reaction is carried out in the absence of water or a combination of these factors is utilised. The invention also relates to the use of ammonia in the production of primary amines by hydrogenation of carboxylic acids and/or derivatives thereof or a process for the production of primary amines generally.