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Usage

Uses

Used in Pharmaceutical Industry:
N-butyl-N-chloro-1-butanamine is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the production of different medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
N-butyl-N-chloro-1-butanamine is used as an intermediate in the production of pesticides. It helps in the development of effective and efficient agrochemicals that protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
N-butyl-N-chloro-1-butanamine is used as a reagent in the preparation of various organic compounds. It aids in the synthesis of a wide range of organic molecules, contributing to the advancement of organic chemistry and its applications.
It is important to handle N-butyl-N-chloro-1-butanamine with care, as it can be harmful if it comes into contact with the skin, eyes, or respiratory system.

Upstream product

• 111-92-2 dibutylamine 
• 4383-27-1 N,N-di-n-butylbenzylamine 

Downstream Products

• 4417-81-6 ethylglyoxal 
• 10264-16-1 N-butyl-butyramide 
• 111-92-2 dibutylamine 
• 109-73-9 N-butylamine 
• 101789-03-1 3-ethoxy-2-(2,4-dinitro-phenylhydrazono)-butyraldehyde-(2,4-dinitro-phenylhydrazone) 
• 6287-40-7 dibutylamine hydrochloride 
• 1563-90-2 N,N-dibutylacetamide 
• 13422-90-7 N-(2-dibutylamino)ethyl chloride 
• 767-10-2 1-butylpyrrolidine 
• 7782-50-5 chlorine 
• 3858-78-4 n-butylamine hydrochloride 
• 92-52-4 biphenyl 
• 613-29-6 N-Dibutylaniline 
• 397-10-4 N,N-dibutyl-3-(trifluoromethyl)aniline 

Relevant academic research and scientific papers

Enantiospecific total synthesis of (+)-tanikolide via a key [2,3]-meisenheimer rearrangement with an allylic amine N-oxide-directed epoxidation and a one-pot trichloroisocyanuric acid N-debenzylation and N-chlorination

The enantiospecific total synthesis of the δ-lactonic marine natural product (+)-tanikolide (1), isolated from Lyngbya majuscula, was achieved using a [2,3]-Meisenheimer rearrangement as the key reaction. During this rearrangement, we discovered that the allylic amine N-oxide could direct the m-CPBA double-bond epoxidation to the syn position. The resulting syn product 8 underwent epoxide ring opening under the m-CBA conditions to give the five- and six-membered cyclic ether amine N-oxides, which we further treated with Zn and conc. HCl to obtain the reduced bisbenzyl tertiary amines 23 and 22, respectively. When 23 and 22 were treated with trichloroisocyanuric acid (TCCA) in dichloromethane, oxidation at the benzyl position occurred, forming iminium ions. These intermediates were trapped by intramolecular reaction with the hydroxyls, and the resulting intermediates were then oxidized or shifted to afford 25 and 24, respectively. The entire one-pot process involves N-debenzylation, N-chlorination, and hemiacetal oxidation. The amine N-oxide-directed epoxidation complements Davies' ammonium-directed epoxidation. Thus, TCCA N-debenzylation is described for the first time and might be a useful N-debenzylation technique.

An insight of the reactions of amines with trichloroisocyanuric acid

The reaction between amines or α-aminoacids with trichloroisocyanuric acid is studied under various conditions: N,N-dichloroamines, nitriles and ketones can be obtained from primary amines, while free aminoacids undergo oxidative decarboxylation to the corresponding nitrile of one less carbon atom.