1026486-55-4

Upstream product

• 193893-12-8 (2R,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-butan-2-ol 
• 143833-83-4 (2S,3R)-2-azido-4-O-(4-methoxybenzyl)butan-1,3,4-triol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 143833-82-3 (2R,3S)-2,3-epoxy-4-O-(4-methoxybenzyl)butan-1,4-diol 
• 143833-81-2 (Z)-4-(4-methoxybenzyloxy)but-2-en-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 193893-09-3 (R)-1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethanol 
• 193893-11-7 Methanesulfonic acid (1R,2R)-2,3-dihydroxy-1-(4-methoxy-benzyloxymethyl)-propyl ester 
• 193893-08-2 (R)-4-[(R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane 
• 193893-10-6 Methanesulfonic acid (R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyloxy)-ethyl ester 

Downstream Products

• 193893-13-9 [(1S,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-hydroxy-3-(4-methoxy-benzyloxy)-propyl]-carbamic acid 2,2,2-trichloro-ethyl ester 
• 1028295-80-8 Benzoic acid (2S,3S)-3-azido-3-[(1S,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-3-(4-methoxy-benzyloxy)-propylcarbamoyl]-2-methoxymethoxy-propyl ester 
• 193893-07-1 (4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-5-trifluoromethanesulfonyloxymethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 193893-15-1 (4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 193893-14-0 (4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 1025823-46-4 C₄₀H₄₆N₄O₉Si 
• 1027505-70-9 C₄₀H₄₄N₄O₉Si 
• 1027557-45-4 C₄₁H₄₈N₂O₈Si 

Relevant academic research and scientific papers

Toward the assignment of liposidomycin stereochemistry: Synthesis of 1,4-diazepan-3-one analogues by reductive amination approach

Toward the assignment of liposidomycin stereochemistry, a stereocontrolled synthesis of the liposidomycin diazepanone ring system and two precursors, has been achieved. The NMR coupling constants of a 5-phenyl model compound closely related to the liposidomycin diazepanone degradation product.

Total synthesis of an enantiomeric pair of FR980482. 2. Syntheses of the aromatic and the optically active aliphatic segments

The synthesis of the aromatic segment 4 was achieved starting from commercially available 5-hydroxyisophthalic acid (6) by utilizing Claisen rearrangement of 9, bromolactonization of 12, and modified Curtius rearrangement of 16 as the key steps. Furthermore, the optically active aliphatic segments 5 and ent-5 were synthesized in enantiomerically pure forms starting with natural (2R, 3R)- and unnatural (2S, 3S)-diethyl tartrate (7 and ent-7), respectively: The synthetic scheme features epoxide formation of 26, nucleophilic epoxide opening of 27 with an azide anion, reduction of the azide function in 33 to an amine, and formation of the N-protected 1,3-oxazolidine 35.