10265-41-5

Upstream product

• 875-04-7 7,7-dimethoxybicyclo<2.2.1>heptene 
• 19448-78-3 1,2,3,4-tetrachloro-7,7-dimethoxybicyclo<2.2.1>hept-2-ene 
• 90254-09-4 (1RS,2SR,4SR)-7,7-dimethoxy-1,4,5,6-tetrachlorobicyclo<2.2.1>hept-5-en-2-ol 
• 64145-55-7 (+/-)-(1S,2S,4S)-7,7-dimethoxybicyclo[2.2.1]hept-5-en-2-ol 
• 10265-39-1 (1R,4S)-7,7-Dimethoxy-bicyclo[2.2.1]heptan-2-one 
• 2207-27-4 5,5-dimethoxy-1,2,3,4-tetrachlorocyclopentadiene 
• 40001-91-0 (+/-)-(1R,2S,4S)-1,4,5,6-tetrachloro-7,7-dimethoxybicyclo[2.2.1]hept-5-en-2-yl acetate 

Downstream Products

• 16205-98-4 3-oxo-cyclohexanecarboxylic acid 
• 73997-59-8 7,7-dimethoxybicyclo<2.2.1>heptan-exo-2-yl half-acid phthalate 
• 73997-64-5 C₁₆H₂₁⁽²⁾HN₂O₄S 
• 73997-64-5 (1R)-3-exo-deuterio-7,7-dimethoxybicyclo<2.2.1>heptan-2-one p-toluenesulfonylhyderazone 
• 53329-08-1 C₁₆H₂₂N₂O₄S 
• 53329-08-1 (1S)-7,7-dimethoxy<2.2.1>heptan-2-one tosylhydrazone 
• 53329-08-1 (1R)-7,7-dimethoxy<2.2.1>heptan-2-one tosylhydrazone 
• 39869-70-0 7,7-dimethoxybicyclo<2.2.1>heptane 

Relevant academic research and scientific papers

Synthesis of the carbobicyclic substructure of CP-225,917 and CP-263,114

The bridgehead alkenic ketones 22a and 22b, representing the carbobicyclic substructure of the squalene synthase and farnesyl transferase inhibitors CP-225,917 (1) and CP-263,114 (23), have been synthesized from the 7-norbornenone acetal 8, using an anion

Synthetic studies related to CP-225,917

Synthetic studies related to CP-225,917 are described, including the preparation of the fully oxygenated tetracyclic central core 3.

ENZYMATIC RESOLUTION OF ENDO-BICYCLOHEPT-2-YL BUTYRATES AND RELATED COMPOUNDS: STERIC REQUIREMENTS IN THE BRIDGE-REGION

Butyrates of endo-bicyclooctanols and endo-bicycloheptan-2-ols, the letter bearing substituents of different size at C-7, were hydrolysed enzymatically using Candida cylindracea lipase.Steric factors were found to influence enantioselection:

An Unusual Occurrence of Chemiluminescence resulting from Metal-Ammonia Reductive Dehalogenation Reactions

Birch type reductive dehalogenation of some members of the series of norbornenes (2a - h), (4i) proceeds with chemiluminescence; an explanation for this phenomenon is advanced.

The Octant Rule. 7. Deuterium as an Octant Pertuber

(1S)-exo-2-Deuteriobicycloheptan-7-one (1) and (1S)-endo-2-deuteriobicycloheptan-7-one (2) were synthesized, and their circular dichroism spectra were measured and analyzed.Both ketones show dissignate Cotton effects near 295 nm corresponding to their n-?* electronic transitions: 1 (Δε296 = +0.033) and 2 (Δε292 = +0.132).The nature of the isotopic perturbation on the n-?* transitions of 1 and 2, related β-deuterioadamantanones and cyclohexanones, and α-deuteriocyclohexanones is treated theoretically.The net contribution to the sign of the rotatory strength is determined by the relatively more consignate contribution on the C-H bond that is located in an oppositely signed octant relative to the C-D bond.