1026549-80-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 220081-32-3 (2R,5S)-2-Benzyl-7-methylsulfanyl-4-oxo-5-(trityl-amino)-heptanoic acid methyl ester 
• 220081-09-4 (S)-6-Methylsulfanyl-3-oxo-4-(trityl-amino)-hexanoic acid allyl ester 
• 80514-68-7 N-trityl-L-methionine 

Relevant academic research and scientific papers

A stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres

A simple, stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres has been developed. N-Tritylated ketomethylene dipeptide isosteres, prepared from N-tritylated amino acids, are converted to their Z- TMS enol ethers and fluorinated with Selectfluor. There is cooperative stereocontrol between the N-tritylamine group and the alkyl group at C-2. The method is short (six steps), diastereoselective (85 → 95%), and enantioselective (>95%).