80514-68-7

Upstream product

• 63-68-3 L-methionine 
• 76-83-5 trityl chloride 
• 10332-17-9 DL-methionine methyl ester 
• 59-51-8 DL-methionine 
• 18598-62-4 N-trityl-DL-methionine methyl ester 
• 5269-64-7 O-(Trimethylsilyl)methionine 

Downstream Products

• 100841-18-7 (S)-(+)-4-Methylthio-2-triphenylmethylamino-1-butanol 
• 83427-81-0 (S)-N-tritylhomoserine lactone 
• 83427-82-1 N-Trityl-S-methyl-methionine sulfonium iodide 
• 220081-09-4 (S)-6-Methylsulfanyl-3-oxo-4-(trityl-amino)-hexanoic acid allyl ester 
• 83427-79-6 N-Trityl-L-homoserine 
• 5088-86-8 p-TosOH*H-Met-ODpm 
• 100841-24-5 Toluene-4-sulfonic acid; compound with (S)-2-amino-4-methylsulfanyl-butan-1-ol 
• 1026549-80-3 (Z)-(2R,5S)-2-Benzyl-7-methylsulfanyl-4-trimethylsilanyloxy-5-(trityl-amino)-hept-3-enoic acid methyl ester 
• 220081-32-3 (2R,5S)-2-Benzyl-7-methylsulfanyl-4-oxo-5-(trityl-amino)-heptanoic acid methyl ester 

Relevant academic research and scientific papers

Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids

For the first time we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C?C bond-forming hydrogen-borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation can be prevented by the use of sub-stoichiometric base and protection of the nitrogen with a sterically hindered triphenylmethane (trityl) or benzyl group. The Ph* and trityl groups are readily cleaved in one pot to give γ-aminobutyric acid (GABA) products as their HCl salts without further purification. Both steps may be performed in sequence without isolation of the hydrogen-borrowing intermediate, removing the need for column chromatography.

Diacylglycerol acyltransferase inhibitors

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Efficient "One-Pot" Synthesis of N-Trityl Amino Acids

A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent