102656-48-4

Upstream product

• 23901-60-2 4-benzylidene-3-methyl-1-phenylpyrazolone 
• 141-97-9 ethyl acetoacetate 
• 39143-05-0 (Z)-4-benzylidene-3-methyl-1-phenyl-1H-pyrazolidinyl-5(4H)-ketone 

Downstream Products

• 112920-97-5 β-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-N-acetyl phenylalanine ethyl ester 
• 112920-98-6 β-(3'-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-phenyl-alanine 

Relevant academic research and scientific papers

Organocatalytic asymmetric one-pot sequential reaction: Synthesis of highly substituted spirocyclohexanepyrazolones with six contiguous stereogenic carbons

An atom-economical synthesis of chiral polyfunctionalized spiropyrazolone derivatives based on the development of a new organocatalytic enantioselective one-pot sequential Michael/Michael/Aldol reaction of 1,3-dicarbonyl compounds with unsaturated pyrazolones and α,β-unsaturated aldehydes has been developed. The notable features of this one-pot sequential process include the generation of up to six consecutive stereogenic carbon centers including one quaternary stereocenter and five tertiary stereocenters with high enantioselectivities (up to 95% ee) and excellent diastereoselectivities (>99:1 d.r.).

Synthesis of Some Pyrazolo-Anisylethylamine Alkaloids Amino Acids and Related Compounds

Schmidt reaction of the pyrazolo-β-(p-anisyl)-propionic acid 3 gave the pyrazolo-anisylethylamine 4.The related alkaloids 5 and 6 were obtained via double Mannich reaction of 4 with the bis-Mannich base of cyclopentanone and transamination with gramine re