39143-05-0

Basic information

• Product Name: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-, (Z)-
• Synonyms: 4-((Z)-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one;(Z)-4-benzylidene-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;4-((Z)-Benzyliden)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-on;1-Phenyl-3-methyl-4-benzyliden-pyrazolon-(5);4-benzylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one
• CAS NO: 39143-05-0
• Molecular Formula: C17H14N2O
• Molecular Weight: 262.311
• Mol File: 39143-05-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-, (Z)-(39143-05-0)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-, (Z)-(39143-05-0)

Safety Data

• Hazardous Substances Data: 39143-05-0(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 1750-36-3 (E)-N-benzylidenebenzenamine 

Downstream Products

• 1422554-85-5 C₂₇H₂₂N₄O₂S 
• 1422555-08-5 C₂₇H₂₂N₄O₂S 
• 1422554-97-9 C₃₃H₂₆N₄O₂S 
• 1422555-01-8 C₂₉H₂₆N₄O₂S 
• 1422555-02-9 C₂₈H₂₄N₄O₂S 
• 1422555-06-3 C₃₈H₃₄N₄O₅ 
• 1422555-04-1 C₃₃H₂₆N₄O₃ 
• 1422555-05-2 C₃₄H₂₈N₄O₂S 

Relevant articles and documents

Highly stereoselective construction of spiro[cyclopropane-1,4′-pyrazolin-5′-one]with 4-arylidene-3-methyl-1-phenyl-pyrazolin-5-one and arsonium ylide

A highly stereoselective synthesis of exo-spiro[cyclopropane-1,4′-pyrazolin-5′-one] from 4-arylidene-3-methyl-1-phenyl-pyrazolin-5-one and arsonium bromide in the presence of base has been achieved. The triphenylarsine-catalyzed cyclopropanation of 4-arylidene-3-methyl-1-phenyl-pyrazolin-5-one with bromide in the presence of NaHCO3 has also been studied. Both exo and endo isomers were formed in this reaction. The structures of the products were characterized by IR, MS, 1H NMR, elemental analysis, and X-ray diffraction analysis.

An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst

The first organocatalytic Michael-cyclization cascade reaction between isothiocyanato oxindoles and unsaturated pyrazolones has been developed. The multicyclic spiro[oxindole/thiobutyrolactam/pyrazolone] core structures containing three contiguous stereog

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists

LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five