102664-14-2Relevant academic research and scientific papers
Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation
Liu, Honghui,Wang, Yan,Lv, Mingxia,Luo, Yi,Liu, Bu-Ming,Huang, Yan,Wang, Mian,Wang, Jianyi
, (2020/10/23)
A series of novel flavonoid analogues were designed and synthesized. The aimed compounds for urease inhibitory activities were clearly superior to the control drug thiourea (more than 10 times). Among these compounds, L2 (IC50 = 1.343 μM) and L12 (IC50 = 1.207 μM) exhibited the most excellent urease inhibitory activity in vitro. The molecular dockings of L2, L12 and L22 into urease were performed to explore the binding modes and their structure-activity relationship. Furthermore, these aimed compounds showed good druggable properties.
An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids
Wang,Liu,Zhang
, p. 1036 - 1041 (2018/07/06)
A number of 4'-substituted (R = H, Me, Cl, F) flavone derivatives is synthesized from 2-hydroxyacetophenones using the modified Baker–Venkataraman reaction. Compound [3-(4-fluorobenzoyl)-5- hydroxy-4'-fluoroflavone] was synthesized for the first time with the yield of 12%. Antiproliferative assays indicate that the synthesized flavones with F substituent at the 4' position demonstrate higher activity than the other flavone derivatives, particularly against HeLa and MCF-7 with the IC50 9.5 and 2.7 μM, respectively.
Facile synthesis of 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5- dicarbethoxy-pyridyl)]-4H-1-benzopyran-4-ones
Soni, Anil Kumar,Krupadanam, G. L. David,Srimannarayana
, p. 795 - 804 (2007/10/03)
Condensation of 8-formyl-7-methoxy-2-phenyl-4H-1-benzopyran-4-ones (5a-f) with ethyl-3-aminocrotonate (6) in glacial acetic acid under Hantzsch conditions afforded 7-methoxy-2-aryl-3-phenyl/or-H-8-[2-(4,6-dimethyl-3,5-dicarbethoxy- pyridyl)]-4H-1-benzopyran-4-ones (7a-f) in good yields. Copyright Taylor & Francis Group, LLC.
