102673-45-0Relevant academic research and scientific papers
Nucleophilic addition of β-amino carbanions to arynes: One-pot synthesis of 4-aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines
Singh, Kamal Nain,Singh, Paramjit,Singh, Pushpinder,Deol, Yadwinder Singh
supporting information; experimental part, p. 2202 - 2205 (2012/06/18)
A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4- tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.
A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines
Venkov, Atanas P.,Vodenicharov, Daniel M.
, p. 253 - 255 (2007/10/02)
1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.
A FACILE SYNTHESIS OF 4-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES: A TOTAL SYNTHESIS OF (+/-)-CHERYLLINE
Hara, Hiroshi,Shirai, Ryuichi,Hoshino, Osamu,Umezawa, Bunsuke
, p. 1945 - 1950 (2007/10/02)
Reaction of benzylamines (3a-d) and styrene oxide at 140 deg C gave quantitavely β-hydroxyphenethylamine (2a-d), acid treatment of which afforded 4-aryl-1,2,3,4-tetrahydroisoquinolines (8a-d) in high yields.On the other hand, the styrene oxide (10 or 15)
