88741-43-9Relevant academic research and scientific papers
Reaction of 5-aryloxazolidines with arylmagnesium bromides as a new route to N-benzyl-β-hydroxyphenethylamines as starting materials for the preparation of 4-aryl-1,2,3,4-tetrahydroisoquinolines
Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Ya.
, p. 2699 - 2702 (2013/06/26)
Benzaldehydes react smoothly with the non-stabilized azomethine ylide derived from sarcosine and formaldehyde to form 5-aryloxazolidines as intermediates, which undergo ring-opening to give N-benzyl-β- hydroxyphenethylamines in good yields by the action o
A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines
Venkov, Atanas P.,Vodenicharov, Daniel M.
, p. 253 - 255 (2007/10/02)
1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.
A FACILE SYNTHESIS OF 4-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES: A TOTAL SYNTHESIS OF (+/-)-CHERYLLINE
Hara, Hiroshi,Shirai, Ryuichi,Hoshino, Osamu,Umezawa, Bunsuke
, p. 1945 - 1950 (2007/10/02)
Reaction of benzylamines (3a-d) and styrene oxide at 140 deg C gave quantitavely β-hydroxyphenethylamine (2a-d), acid treatment of which afforded 4-aryl-1,2,3,4-tetrahydroisoquinolines (8a-d) in high yields.On the other hand, the styrene oxide (10 or 15)
