1026774-20-8Relevant articles and documents
Nitrated indenoisoquinolines as topoisomerase I inhibitors: A systematic study and optimization
Morrell, Andrew,Placzek, Michael,Parmley, Seth,Antony, Smitha,Dexheimer, Thomas S.,Pommier, Yves,Cushman, Mark
, p. 4419 - 4430 (2007)
The biological activity of indenoisoquinoline topoisomerase I (Top1) inhibitors can be greatly enhanced depending on the choice of substituents on the aromatic rings and lactam side chain. Previously, it was discovered that a 3-nitro group and a 9-methoxy
Reactivity of N-(ω-haloalkyl)-β-lactams with regard to lithium aluminium hydride: Novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridines and 3-aryl-3-(N-propylamino)propan-1-ols
D'Hooghe, Matthias,Dekeukeleire, Stijn,De Kimpe, Norbert
experimental part, p. 1190 - 1196 (2008/10/09)
The reactivity of 4-aryl-1-(2-chloroethyl)azetidin-2-ones and 4-aryl-1-(3-bromopropyl)azetidin-2-ones with regard to lithium aluminium hydride has been evaluated for the first time. 4-Aryl-1-(2-chloroethyl)azetidin-2-ones were transformed into novel 1-(1-