7730-39-4Relevant academic research and scientific papers
Microwave-assisted synthesis of azetidines in aqueous media
Burkett, Brendan A.,Ting, Samuel Z.,Gan, Gwendolyn C. S.,Chai, Christina L. L.
supporting information; experimental part, p. 6590 - 6592 (2011/02/23)
Simple azetidines are synthesized in good to excellent yields and high purity via cyclization of 3-(ammo-nio)propyl sulfates derived from primary amines and the cyclic sulfate of 1,3-propanediol. A feature of this methodology includes the accelerated synt
Mechanistic considerations for the consecutive cyclization of 2,3-dibromopropylamine hydrobromide giving a strained molecule, 1-azabicyclo[1.1.0]butane
Hayashi, Kazuhiko,Ikee, Yoshifumi,Goto, Satoru,Shiro, Motoo,Nagao, Yoshimitsu
, p. 89 - 94 (2007/10/03)
The effective formation of 1-azabicyclo[1.1.0]butane (2) by treatment of 2,3-dibromopropylamine hydrobromide (1) with n-BuLi could be understood considering a rational reaction pathway via both transition states 10 and 19 based on the intramolecular Br...
A facile and efficient synthesis of N-benzylazetidine
Lai
, p. 565 - 568 (2007/10/03)
An efficient, two-step synthesis of N-benzylazetidine, starting from benzaldehyde and 3-bromopropylamine hydrobromide, is described.
Synthesis of aziridines and acetidines from N-(ω-haloalkyl) imines
De Kimpe,De Smaele
, p. 8023 - 8026 (2007/10/02)
N-(2-haloalkyl) and N-(3-haloalkyl) imines are convenient substrates for the synthesis of aziridines and azetidines via a two-step process involving nucleophile induced addition at the imino bond followed by intramolecular nucleophilic substitution.
Preparation of Azetidines from 1,3-Aminopropanols
Sammes, Peter G.,Smith, Steven
, p. 2415 - 2420 (2007/10/02)
The preparation of 1,3-amino alcohols by the reduction of azetidin-2-ones with diborane is described.New methods for the cyclisation of the aminopropanols to the corresponding azetidines are reported; these methods centre on the use of a modified Mitsunobu reaction.
On the Synthesis of Azetidines from 3-Hydroxypropylamines
Sammes, Peter G.,Smith, Steven
, p. 682 - 684 (2007/10/02)
New methods are described for preparing azetidines from 3-hydroxypropylamines involving the use of triphenylphosphine and diethyl azodicarboxylate and related reagents.
