10268-06-1

Basic information

• Product Name: 2-(2-Chlorophenyl)acetaMide
• Synonyms: 2-(2-Chlorophenyl)acetaMide;2-chloroBenzeneacetamide;2-(o-Chlorophenyl)acetamide;2-(2-Chlorophenyl)
• CAS NO: 10268-06-1
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 10268-06-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-Chlorophenyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chlorophenyl)acetaMide(10268-06-1)
• EPA Substance Registry System: 2-(2-Chlorophenyl)acetaMide(10268-06-1)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 10268-06-1(Hazardous Substances Data)

Usage

General Description

2-(2-Chlorophenyl)acetamide is a chemical compound with the molecular formula C8H8ClNO. It is an amide derivative of 2-chloroacetophenone and is often used as an intermediate in the synthesis of pharmaceutical compounds. This chemical is white to off-white in appearance and is insoluble in water but soluble in organic solvents such as ethanol and ether. It is commonly used in the pharmaceutical industry for the production of various drugs and medications. The compound is also known for its mild analgesic and anti-inflammatory properties and is used in the preparation of various pain-relieving formulations. Overall, 2-(2-Chlorophenyl)acetamide is an important intermediate in organic synthesis and is widely utilized in pharmaceutical research and development.

Upstream product

• 2856-63-5 2-Chlorophenylacetonitrile 
• 942625-95-8 1-(trimethylsiloxy)-1-o-chloro-phenylethene 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 71512-21-5 2-(2-chlorophenyl)-N-phenylacetamide 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 626603-93-8 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione 
• 59-48-3 2-oxoindole 
• 475201-00-4 methyl N-(2-chlorobenzyl)carbamate 
• 92435-52-4 1-(2-chlorophenyl)-3-phenyl-2-propanone 
• 2444-36-2 2'-chloro-benzeneacetic acid 

Relevant articles and documents

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging

Dysregulation of glycogen synthase kinase-3β (GSK-3β) is implicated in the pathogenesis of neurodegenerative and psychiatric disorders. Thus, development of GSK-3β radiotracers for positron emission tomography (PET) imaging is of paramount importance, because such a noninvasive imaging technique would allow better understanding of the link between the activity of GSK-3β and central nervous system disorders in living organisms, and it would enable early detection of the enzyme’s aberrant activity. Herein, we report the synthesis and biological evaluation of a series of fluorine-substituted maleimide derivatives that are high-affinity GSK-3β inhibitors. Radiosynthesis of a potential GSK-3β tracer [18F]10a is achieved. Preliminary in vivo PET imaging studies in rodents show moderate brain uptake, although no saturable binding was observed in the brain. Further refinement of the lead scaffold to develop potent [18F]-labeled GSK-3 radiotracers for PET imaging of the central nervous system is warranted.

Amberlyst A26 OH as a recyclable catalyst for hydration of nitriles and water-based synthesis of 4(1 H)-quinazolinones from 2-aminobenzonitrile and carbonyl compounds

Selective hydration of nitriles to primary amides as well the base-catalyzed synthesis of 2-substituted 4(1H)-quinazolinones via reaction of 2-aminobenzonitrile with carbonyl compounds using macroporous Amberlyst A26 OH in H2O-EtOH is described. The latter reaction proceeds via tandem hydration of 2-aminobenzonitrile, condensation of the in situ generated 2-aminobenzamide with carbonyl compounds, and cyclization of the imine intermediate to give the quinazolinone derivatives. Georg Thieme Verlag Stuttgart New York.

Synthesis of α-Arylcarboxylic acid amides from silyl enol ether via migratory Amidation with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate

α-Arylcarboxylic acid amides were synthesized by reacting silyl enol ethers of aryl ketones and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP,1). Silyl enol ethers react with ADMP 1 to give N-(α-arylacyl) guanidines via the migration of aryl groups in enol ethers. The products were transformed to the corresponding α-aryl acetamides by treating with LiAlH4.