10268-50-5Relevant articles and documents
Three-component metal-free arylation of isocyanides
Basavanag, Unnamatla M. V.,Dos Santos, Aurelie,El Kaim, Laurent,Gamez-Montano, Rocio,Grimaud, Laurence
, (2013)
Mumm's the word: The title reaction can be performed by the addition of isocyanides to benzenediazonium salts in the presence of sodium or potassium carboxylates. The reaction involves nitrilium intermediates which may be trapped by water or carboxylic ac
A rapid and convenient synthesis of amides from aromatic acids and aliphatic amines in dry media under microwave irradiation
Hajipour,Ghasemi
, p. 504 - 507 (2007/10/03)
The synthesis of amides 2 from the corresponding aromatic acids and aliphatic amines in the presence of catalytic amount of p-toluenesulfonic acid has been reported. The reactions are accelerated with microwave irradiation under solvent-free conditions to afford a high yielding synthesis of amides.
1-(4-Aminobenzyl)- and 1-(4-aminophenyl)isoquinoline derivatives: Synthesis and evaluation as potential irreversible cyclic nucleotide phosphodiesterase inhibitors
Walker,Boots,Stubbins,Rogers,Davis
, p. 174 - 181 (2007/10/02)
In an effort to increase the specificity of the potent phosphodiesterase inhibitor papaverine, we synthesized two series of novel 1-(4-aminobenzyl)- and 1-(4-aminophenyl)isoquinoline derivatives, incorporating alkylating moieties on the amine substituents. These compounds were evaluated for their inhibitory action on phosphodiesterase preparations from bovine heart and rat cerebral cortex. Studies were also conducted to determine whether these compounds were reacting with the enzymes in an irreversible manner. The compounds were potent inhibitors of the phosphodiesterases; however, no evidence was found for an irreversible inhibition.
