83633-14-1 Usage
Also known as
ABT-908
Property
Potent and selective inhibitor of methionine aminopeptidase-1 (MetAP-1)
Function
Enzyme involved in the regulation of protein synthesis and angiogenesis
Therapeutic applications
Studied for potential use in cancer treatment, inhibiting tumor cell growth and showing promising results in preclinical studies
Other potential uses
Investigated for use in inflammatory diseases and conditions related to abnormal protein synthesis
Status
Currently undergoing clinical trials to evaluate safety and efficacy for potential indications
Check Digit Verification of cas no
The CAS Registry Mumber 83633-14-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,6,3 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 83633-14:
(7*8)+(6*3)+(5*6)+(4*3)+(3*3)+(2*1)+(1*4)=131
131 % 10 = 1
So 83633-14-1 is a valid CAS Registry Number.
83633-14-1Relevant academic research and scientific papers
1-(4-Aminobenzyl)- and 1-(4-aminophenyl)isoquinoline derivatives: Synthesis and evaluation as potential irreversible cyclic nucleotide phosphodiesterase inhibitors
Walker,Boots,Stubbins,Rogers,Davis
, p. 174 - 181 (2007/10/02)
In an effort to increase the specificity of the potent phosphodiesterase inhibitor papaverine, we synthesized two series of novel 1-(4-aminobenzyl)- and 1-(4-aminophenyl)isoquinoline derivatives, incorporating alkylating moieties on the amine substituents. These compounds were evaluated for their inhibitory action on phosphodiesterase preparations from bovine heart and rat cerebral cortex. Studies were also conducted to determine whether these compounds were reacting with the enzymes in an irreversible manner. The compounds were potent inhibitors of the phosphodiesterases; however, no evidence was found for an irreversible inhibition.
