1027027-41-3Relevant articles and documents
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines
Natchus,Bookland,Laufersweiler,Pikul,Almstead,De,Janusz,Hsieh,Gu,Pokross,Patel,Garver,Peng,Branch,King,Baker,Foltz,Mieling
, p. 1060 - 1071 (2007/10/03)
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typically
