10271-85-9

Basic information

• Product Name: 5-ISOTHIAZOLECARBOXYLIC ACID
• Synonyms: 5-ISOTHIAZOLECARBOXYLIC ACID;ISOTHIAZOLE-5-CARBOXYLIC ACID;8-Isoquinoline-methaneaminedihydrochloride;1,2-thiazole-5-carboxylic acid
• CAS NO: 10271-85-9
• Molecular Formula: C₄H₃NO₂S
• Molecular Weight: 129.14
• Mol File: 10271-85-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 196-200℃ (分解)
• Boiling Point: 178.4±23.0℃ (760 Torr)
• Flash Point: 61.7±22.6℃
• Appearance: /
• Density: 1.525±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.65mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• PKA: 1.23±0.10(Predicted)
• CAS DataBase Reference: 5-ISOTHIAZOLECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ISOTHIAZOLECARBOXYLIC ACID(10271-85-9)
• EPA Substance Registry System: 5-ISOTHIAZOLECARBOXYLIC ACID(10271-85-9)

Safety Data

• Hazardous Substances Data: 10271-85-9(Hazardous Substances Data)

Usage

General Description

5-Isothiazolecarboxylic acid is a heterocyclic organic compound with the molecular formula C4H3NOS. It is a derivative of isothiazole and carboxylic acid, and is used in the synthesis of pharmaceuticals and other organic compounds. It is a colorless to pale yellow solid with a slightly unpleasant odor. 5-Isothiazolecarboxylic acid is known for its antimicrobial and antifungal properties, and it is used as an intermediate in the production of drugs and agrochemicals. It is also used as a building block in organic chemistry and is an important chemical in the field of medicinal chemistry.

InChI:InChI=1/C4H3NO2S/c6-4(7)3-1-2-5-8-3/h1-2H,(H,6,7)

Upstream product

• 693-97-0 5-methylisothiazole 
• 288-16-4 isothiazol 
• 124-38-9 carbon dioxide 
• 15901-66-3 methyl isothiazole-5-carboxylate 

Downstream Products

• 89033-31-8 isothiazole-5-carboxylic acid hydrazide 

Relevant articles and documents

CARBOXYLATION CATALYSTS

The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.

Methods for inhibiting protein kinases

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS

This invention relates to compounds, in particular benzimidazoles, that are useful as estrogen agonists and/or antagonists and pharmaceutical uses thereof. The present invention also relates to benzimidazoles that are selective for the ER? receptor and pharmaceutical uses thereof.