1027159-92-7Relevant academic research and scientific papers
(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase
Lampe,Chou,Hanna,Di Meo,Erhardt,Hagedorn III,Ingebretsen,Cantor
, p. 1041 - 1047 (2007/10/02)
Seven 3-alkyl-4-aryl-1,5-dihydro-2H-pyrrol-2-ones were prepared as potential inhibitors of cardiac cAMP phosphodiesterase (PDE). The design of these compounds made use of rolipram, a known inhibitor of the brain cAMP PDE isozyme, as a lead structure and w
