102729-41-9Relevant academic research and scientific papers
Synthesis of 2-arylquinoxalines: Triarylstibane-catalyzed oxidative cyclization of α-hydroxy ketones with 1,2-diamines under aerobic conditions
Matsumura, Mio,Takada, Rie,Ukai, Yuu,Yamada, Mizuki,Murata, Yuki,Kakusawa, Naoki,Yasuike, Shuji
, p. 75 - 83 (2016)
The reaction of α-hydroxy ketones with 1,2-diamines in the presence of triphenylstibane (10 mol%) as catalyst led to the formation of 2-arylquinoxalines in moderate to good yield under aerobic conditions. This reaction is the first example of oxidative cy
A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors
Lei, Hong-Xu,Zhang, KaiLi,Qin, Yu-Xi,Dong, Rong-Jian,Chen, De-Zhan,Zhou, HaiFeng,Sheng, Xie-Huang
, (2020/11/10)
Ferroptosis is a recently characterized form of regulated necrosis with the iron-dependent accumulation of (phospho)lipid hydroperoxides (LOOH). It has attracted considerable attention for its putative involvement in diverse pathophysiological processes, such as cardiovascular disease and neurodegeneration. Here we describe the discovery of tetrahydroquinoxaline, a novel scaffold of ferroptosis inhibitors based on quantum chemistry methods. Tetrahydroquinoxaline deviates showed very good inhibition of ferroptosis, while being non cytotoxic for human cancer cells. And, the advantage of them is their small molecular weight (MW. = 148 Da) that can be coupled with other drugs to form multi-target drugs to better meet the treatment of complicated diseases.
Iridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives
Che, Tong,Kang, Hua-Jie,Peng, Dongming,Shu, Bing,Song, Jia-Lin,Wang, Xiao-Tong,Xie, Hui,Zhang, Luyong,Zhang, Shang-Shi,Zhong, Mei
, (2020/06/25)
A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds.
Catalyst-free synthesis of quinoxalines
Lu, Dongming,Xiang, Qinjie,Zhou, Lihong,Zeng, Qingle
, p. 2639 - 2641 (2015/12/12)
Quinoxalines are a class of important heterocycles, so to explore a facile and practical new synthetic method is always demanded. We have developed a new catalyst-free domino synthesis of quinoxalines from phenacyl halides and 1,2-diaminoarenes. Phenacyl
Gold-catalyzed synthesis of glyoxals by oxidation of terminal alkynes: One-pot synthesis of quinoxalines
Shi, Shuai,Wang, Tao,Yang, Weibo,Rudolph, Matthias,Hashmi, A. Stephen K.
, p. 6576 - 6580 (2013/06/27)
From terminal alkynes to glyoxals: Terminal alkynes can be oxidized under mild conditions by the use of an N-oxide in the presence of a gold catalyst. The intermediate glyoxal derivatives can be transferred in a one-pot procedure to substituted quinoxalines (see scheme). Copyright
2-Phenyl-(6(7)-R-substituted quinoxalines N-oxides. Synthesis, structure elucidation and antimicrobial activity
Loriga,Nuvole,Paglietti,Fadda,Zanetti
, p. 527 - 532 (2007/10/02)
A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6/7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis ac
