102729-49-7

Upstream product

• 102729-48-6 3-chloro-2-phenyl-6-trifluoromethylquinoxaline 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 611-73-4 Benzoylformic acid 
• 2835-06-5 phenylglycin 
• 102729-47-5 3-phenyl-7-trifluoromethylquinoxalin-2(1H)-one 
• 102729-46-4 3,4-dihydro-3-phenyl-7-trifluoromethylquinoxalin-2(1H)-one 
• 102729-45-3 N-(2-nitro-4-trifluoromethylphenyl)phenylglycine 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 102729-50-0 3,4-dihydro-3-methyl-2-phenyl-6-trifluoromethylquinoxaline 
• 102729-55-5 2-methyl-3-phenyl-7-trifluoromethylquinoxaline 1-oxide 
• 102729-53-3 3-phenyl-7-trifluoromethylquinoxaline N-oxide 
• 102729-43-1 3-methyl-2-phenyl-6-trifluoromethylquinoxaline 
• 102729-41-9 2-phenyl-6-(trifluoromethyl)quinoxaline 

Relevant academic research and scientific papers

A quantum-chemical approach to develop tetrahydroquinoxaline as potent ferroptosis inhibitors

Ferroptosis is a recently characterized form of regulated necrosis with the iron-dependent accumulation of (phospho)lipid hydroperoxides (LOOH). It has attracted considerable attention for its putative involvement in diverse pathophysiological processes, such as cardiovascular disease and neurodegeneration. Here we describe the discovery of tetrahydroquinoxaline, a novel scaffold of ferroptosis inhibitors based on quantum chemistry methods. Tetrahydroquinoxaline deviates showed very good inhibition of ferroptosis, while being non cytotoxic for human cancer cells. And, the advantage of them is their small molecular weight (MW. = 148 Da) that can be coupled with other drugs to form multi-target drugs to better meet the treatment of complicated diseases.

Tetrahydroquinoxaline compound, and preparation method and application thereof

The invention provides a tetrahydroquinoxaline compound, and a preparation method and application thereof. The chemical structure is shown in a formula I: the tetrahydroquinoxaline compound has good cell ferroptosis inhibition activity, and can be used fo