1027343-46-9

Basic information

• Product Name: C₁₈H₂₆BrClN₂O₂
• CAS NO: 1027343-46-9
• Molecular Weight: 417.774
• Mol File: 1027343-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₆BrClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₆BrClN₂O₂(1027343-46-9)
• EPA Substance Registry System: C₁₈H₂₆BrClN₂O₂(1027343-46-9)

Safety Data

• Hazardous Substances Data: 1027343-46-9(Hazardous Substances Data)

Upstream product

• 66192-24-3 2-bromo-5-chlorobenzyl bromide 
• 147539-41-1 4-methylamino-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1027344-25-7 C₁₃H₁₈BrClN₂ 

Relevant articles and documents

Discovery of a series of aminopiperidines as novel iNOS inhibitors

Nitric oxide (NO), a mediator of various physiological and pathophysiological processes, is synthesized by three isozymes of nitric oxide synthase (NOS). Potential candidate clinical drugs should be devoid of inhibitory activity against endothelial NOS (eNOS), since eNOS plays an important role in maintaining normal blood pressure and flow. A new series of aminopiperidines as potent inhibitors of iNOS were identified from a HTS lead. From this study, we identified compound 33 as a potent iNOS inhibitor, with >25-fold selectivity over eNOS and 16-fold selectivity over nNOS.