1027513-67-2 Usage
Derivative of piperidine
Heterocyclic organic compound 1-naphthalen-2-ylmethyl-piperidin-3-ylamine is derived from piperidine, which is a heterocyclic organic compound consisting of a six-membered ring containing five carbon atoms and one nitrogen atom.
Use in pharmaceutical industry
Precursor in drug synthesis The compound is used as a precursor in the synthesis of various drugs, meaning it serves as a starting material that can be chemically modified to produce different active pharmaceutical ingredients.
Building block in complex organic molecules
Creation of other molecules 1-naphthalen-2-ylmethyl-piperidin-3-ylamine can also be used as a building block in the creation of other complex organic molecules, making it a versatile compound in organic synthesis.
Therapeutic potential
Treatment of neurological and psychiatric disorders The compound has been studied for its potential therapeutic applications, particularly in the treatment of neurological and psychiatric disorders, due to its unique structure and properties.
Research and drug development
Valuable tool The structure and properties of 1-naphthalen-2-ylmethyl-piperidin-3-ylamine make it a valuable tool for further research and drug development efforts, as it can be used to create new compounds and study their effects on various biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1027513-67-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,7,5,1 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1027513-67:
(9*1)+(8*0)+(7*2)+(6*7)+(5*5)+(4*1)+(3*3)+(2*6)+(1*7)=122
122 % 10 = 2
So 1027513-67-2 is a valid CAS Registry Number.
1027513-67-2Relevant articles and documents
Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity
Kim, Nick,Meyers, Kenneth M.,Mendez-Andino, Jose L.,Warshakoon, Namal C.,Ji, Wei,Wos, John A.,Colson, Annyodile,Mitchell, M. Chrissy,Davis, Jan R.,Pinney, Beth B.,Reizes, Ofer,Hu, X. Eric
, p. 5445 - 5450 (2006)
A substituted 4-aminopiperidine was identified as showing activity in an MCH assay from an HTS effort. Subsequent structural modification of the scaffold led to the identification of a number of active MCH antagonists. 3,5-Dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-yl)benzamide (5c) was among those with the highest binding affinity to the MCH receptor (Ki = 27 nM), when variations were made at benzoyl and naphthylmethyl substitution sites from the initial HTS hit. Further optimization via piperidine ring contraction resulted in enhanced MCH activity in a 3-aminopyrrolidine series, where (R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)-pyrrolidin-3-yl)benzamide (10i) was found to be an excellent MCH antagonist (Ki = 7 nM).
