1027513-99-0

Basic information

• Product Name: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid
• Synonyms: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid
• CAS NO: 1027513-99-0
• Molecular Weight: 202.158
• Mol File: 1027513-99-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid(1027513-99-0)
• EPA Substance Registry System: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid(1027513-99-0)

Safety Data

• Hazardous Substances Data: 1027513-99-0(Hazardous Substances Data)

Usage

Physical appearance

White crystalline solid The compound forms a white, crystal-like structure when in its solid state.

Classification

Fluorinated aromatic carboxylic acid It belongs to a class of compounds that have a fluorinated (containing fluorine) aromatic ring and a carboxylic acid functional group.

Uses

Intermediate in synthesis of pharmaceuticals and agrochemicals The compound is commonly used as a starting material or building block in the production of various drugs and agricultural chemicals.

Potential applications

Treatment of viral infections Research has shown that 2,2-difluoro-2-(3-methoxyphenyl)acetic acid may have potential therapeutic uses in treating certain viral infections.

Unique properties

Biological activity and reactivity The presence of difluoro and methoxy groups in the compound's structure contribute to its ability to interact with biological systems and undergo chemical reactions, making it a valuable component in medicinal chemistry and drug development.

Versatility

Synthesis of various organic compounds Due to its unique properties and reactivity, 2,2-difluoro-2-(3-methoxyphenyl)acetic acid can be used as a building block for the synthesis of a wide range of organic compounds, making it an important chemical in the field of medicinal chemistry and drug development.

Upstream product

• 766-85-8 3-methoxy-1-iodobenzene 
• 667-27-6 Ethyl bromodifluoroacetate 
• 915133-57-2 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester 

Downstream Products

• 454-90-0 3-(trifluoromethyl)anisole 

Relevant articles and documents

Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with α,α-Difluoroarylacetic Acids

A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.

Copper-catalyzed cascade radical cyclization of alkynoates: Construction of aryldifluoromethylated coumarins

A mild and simple method is reported for the construction of 3-difluoroarylmethylated coumarins using α,α-difluoroarylacetic acids as an easily handled difluoromethyl source in reaction with ester 3-arylpropiolates under the promotion of copper. The reaction involves a proposed radical-triggered domino decarboxylative aryldifluoromethylation/5-exo cyclization/ester migration process that directly forms Csp2-CF2Ar and C-C bonds with good functional group tolerance. This journal is

Silver-Catalyzed Decarboxylative Radical Addition/Cyclization of α,α-Difluoroarylacetic Acids with Acrylamides To Synthesize Difluorinated Oxindoles

A facile silver-catalyzed decarboxylative radical addition/cyclization reaction of α,α-difluoroarylacetic acids and acrylamides has been disclosed. The method provides a highly attractive approach to synthesize a series of difluorinated oxindoles that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF2 group of the α,α-difluoroarylacetic acids plays a vital role in the transformation.