1027582-83-7Relevant academic research and scientific papers
A Concise and Stereoselective Total Synthesis of Pestalotioprolide C Using Ring-Closing Metathesis
Kundoor, Govinda Reddy,Battina, Suresh Kumar,Krishna, Palakodety Radha
, p. 1152 - 1158 (2018)
The stereoselective total synthesis of the pestalotioprolide C is disclosed in 13 linear steps in 4% overall yield. The key steps in this approach are a ring-closing-metathesis protocol for the construction of the 14-membered macrolide with E -olefinic bo
First Total Synthesis of the Proposed Structure of Pandangolide 1
Show, Krishanu,Gonnade, Rajesh G.,Kumar, Pradeep
, p. 3352 - 3364 (2018/07/13)
The first total synthesis of the proposed structure of pandangolide 1 is reported. The synthesis was carried out using both an organocatalytic approach and a chiral-pool approach. The required stereochemistry at C-3 and C-5 was installed by using an organocatalytic aldol reaction and a stereoselective ketone reduction. The construction of the 12-membered core was achieved by 2-methyl-6-nitrobenzoic anhydride-mediated Shiina lactonization. The structure of target molecule was confirmed unambiguously by single-crystal X-ray analysis, but the optical rotation and NMR spectroscopic data of the synthetic pandangolide 1 were found to be inconsistent with the natural product.
First synthesis and determination of the absolute stereochemistry of iso-cladospolide-B and cladospolides-B and C
Sharma,Laxmi Reddy,Janardhan Reddy
, p. 6537 - 6540 (2007/10/03)
The syntheses of iso-cladospolide-B, cladospolide-B and cladospolide-C are reported with 4S,5S,11S-configuration. Of the three stereogenic centres, the C-4/C-5 vic-diol was created by Evans aldol condensation, while the C-11 stereocentre was created by Ja
