1027708-01-5Relevant academic research and scientific papers
Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J.,Poisson, Carl,Ardzinski, Andrzej,Bilimoria, Darius,Chan, Laval,Chandupatla, Kishan,Chauret, Nathalie,Collier, Philip N.,Das, Sanjoy Kumar,Denis, Francois,Dorsch, Warren,Iyer, Ganesh,Lauffer, David,L'Heureux, Lucille,Li, Pan,Luisi, Brian S.,Mani, Nagraj,Nanthakumar, Suganthi,Nicolas, Olivier,Rao, B. Govinda,Ronkin, Steven,Selliah, Subajini,Shawgo, Rebecca S.,Tang, Qing,Waal, Nathan D.,Yannopoulos, Constantin G.,Green, Jeremy
, p. 6293 - 6302 (2016)
The hepatitis C viral proteins NS3/4A protease, NS5B polymerase, and NS5A are clinically validated targets for direct-acting antiviral therapies. The NS5B polymerase may be inhibited directly through the action of nucleosides or nucleotide analogues or al
3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS
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Page/Page column 33, (2009/03/07)
The present invention relates to novel 2-carboxy thiophene compounds of the formula (I): and salts thereof, to pharmaceutical compositions containing them and their use in medicine, as anti-viral agents. Specifically, the present invention relates to comp
