102771-00-6

Basic information

• Product Name: 2-Iodo-5-(trifluoroMethyl)phenol
• Synonyms: 2-Iodo-5-(trifluoroMethyl)phenol;PHENOL,2-IODO-5-(TRIFLUOROMETHYL)-
• CAS NO: 102771-00-6
• Molecular Formula: C₇H₄F₃IO
• Molecular Weight: 288.0057396
• Mol File: 102771-00-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 201.3°C at 760 mmHg
• Flash Point: 75.5°C
• Appearance: /
• Density: 2.007g/cm³
• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: 1.554
• PKA: 7.51±0.10(Predicted)
• CAS DataBase Reference: 2-Iodo-5-(trifluoroMethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-(trifluoroMethyl)phenol(102771-00-6)
• EPA Substance Registry System: 2-Iodo-5-(trifluoroMethyl)phenol(102771-00-6)

Safety Data

• Hazardous Substances Data: 102771-00-6(Hazardous Substances Data)

Usage

General Description

2-Iodo-5-(trifluoroMethyl)phenol is a chemical compound with the molecular formula C7H4F3IO. It is a halogenated phenolic compound that contains a trifluoromethyl group. 2-Iodo-5-(trifluoroMethyl)phenol is used as a reagent in organic synthesis and has potential applications in the pharmaceutical industry. It is also used as a building block for the synthesis of various biologically active compounds. The presence of the iodo and trifluoromethyl groups in the molecule gives it unique chemical properties, making it useful in different chemical reactions and processes. Additionally, it is important to handle this compound with caution, as it is a potentially hazardous material and should be used in a controlled environment with proper safety measures in place.

InChI:InChI=1/C7H4F3IO/c8-7(9,10)4-1-2-5(11)6(12)3-4/h1-3,12H

Upstream product

• 334018-79-0 1-(trifluoromethyl)-3-(methoxymethoxy)benzene 
• 956219-18-4 C₁₁H₁₂F₃NO₂ 
• 98-17-9 3-Trifluoromethylphenol 

Downstream Products

• 920334-20-9 3-(5-methoxycarbonyl-4-penten)oxy-4-iodo-trifluoromethylbenzene 
• 1449696-93-8 6,6′-(ethyne-1,2-diyl)bis[3-(trifluoromethyl)phenol] 
• 1449697-00-0 1,2-bis[2-(methoxymethoxy)-4-(trifluoromethyl)phenyl]ethyne 
• 1261752-45-7 1-iodo-2-methoxy-4-(trifluoromethyl)benzene 
• 1379680-40-6 C₃₈H₂₆F₆P₂ 
• 1379680-39-3 C₃₈H₂₆F₆O₂P₂ 
• 337529-30-3 [1R-[1α(Z),2β(1E),3α,5α]]-7-[5-hydroxy-2-[[4-(2-iodo-5-trifluoromethyl)phenoxy]-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butenyl]-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]-5-heptenoic acid 1-methylethyl ester 

Relevant articles and documents

Visible-Light-Induced Radical Carbo-Cyclization/ gem-Diborylation through Triplet Energy Transfer between a Gold Catalyst and Aryl Iodides

Geminal diboronates have attracted significant attention because of their unique structures and reactivity. However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown. A promising protocol using visible light and aryl iodides for constructing valuable building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presented. The utility of these gem-diboronates has been demonstrated by a 10 g scale conversion, by versatile transformations, by including the synthesis of approved drug scaffolds and two approved drugs, and even by polymer synthesis. The mechanistic investigation indicates that the merging of the dinuclear gold catalyst (photoexcitation by 315-400 nm UVA light) with Na2CO3 is directly responsible for photosensitization of aryl iodides (photoexcitation by 254 nm UV light) with blue LED light (410-490 nm, λmax = 465 nm) through an energy transfer (EnT) process, followed by homolytic cleavage of the C-I bond in the aryl iodide substrates.

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

Exploring the potential of diarylacetylenediols as hydrogen bonding catalysts

In the course of a search for new classes of hydrogen bonding catalysts, we have examined diarylacetylenediols as potential catalysts for the Diels-Alder reaction. General and efficient methods have been developed for the preparation of these diols. Their structures were systematically modified, and increased activity was observed for those possessing an electron-withdrawing group on the aryl groups. The electron-deficient diarylacetylenediol catalysts, while more active, undergo spontaneous cyclization to the corresponding benzo[b]furans. A mechanism is postulated to explain this facile transformation. Computational studies performed on 2-ethynylphenol help to explain the effect of the alkyne on the conformation and hydrogen bond donating ability of the adjacent OH group. Finally, the crystal structure of one of the diols is reported, and it displays an intricate network of intermolecular hydrogen bonds.