1261752-45-7

Usage

Halogenated aromatic compound

A compound containing one or more halogen atoms (such as fluorine, chlorine, bromine, or iodine) attached to a benzene ring.

Trifluoromethyl group

A functional group consisting of three fluorine atoms bonded to a single carbon atom.

Iodine atom

A halogen element present in the compound, attached to the benzene ring.

Methoxy group

A functional group consisting of an oxygen atom bonded to a carbon atom in a molecule.

Organic synthesis

The process of preparing organic compounds through chemical reactions, commonly used in the synthesis of complex molecules.

Starting material

A simple compound used as the base for creating more complex organic compounds through chemical reactions.

Pharmaceutical industry

The industry focused on the development, production, and marketing of medications for medical treatment.

Agrochemical industry

The industry involved in the production and distribution of chemical products for agriculture, such as pesticides, herbicides, and fertilizers.

Unique chemical properties

Distinct characteristics of the compound that set it apart from other similar compounds, influencing its reactivity and potential applications.

Reactivity

The compound's ability to undergo chemical reactions with other substances, influenced by its molecular structure and functional groups.

Safety precautions

Measures and practices taken to minimize the risk of harm when handling potentially hazardous chemicals, including proper storage, disposal, and personal protective equipment.

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 102771-00-6 2-iodo-5-(trifluoromethyl)phenol 
• 74-88-4 methyl iodide 

Downstream Products

• 1379680-39-3 C₃₈H₂₆F₆O₂P₂ 
• 1379680-40-6 C₃₈H₂₆F₆P₂ 

Relevant academic research and scientific papers

NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF

The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions

Not only electronic but also steric effects of 4,4′-substituents in BIPHEP derivatives and metal (Pd, Pt, and Au) complexes are shown to influence the stability of the biphenyl single bond rotation. While electron-donating or sterically demanding substituents on the 4,4′-positions destabilize the axial chirality of BIPHEP derivatives, electron-withdrawing or sterically less demanding ones on the 4,4′-positions stabilize the axis chirality. Particularly, the axial chirality of palladium dichloride complexes bearing BIPHEP with t-Bu and CF3 substituents on the 4,4′-positions is most labile and stable, respectively (ΔG≠ = 29.22 and 30.49 kcal mol-1 at 300 K; t1/2 = 7 and 56 years at 300 K). These enantiopure dicationic BIPHEPPd complexes can be employed for catalytic enantioselective arylation, alkenylation, and ene reactions to give the corresponding products in good-to-excellent yields and enantioselectivities. Significantly, in the carbonyl-ene reaction of trifluoropyruvate with isobutene, the turnover frequency (TOF) reached 58200 h-1. The remarkable effects of 4,4′-substituents in BIPHEP derivatives can be employed as a guiding principle in the design of versatile and efficient ligands.