1027786-85-1Relevant academic research and scientific papers
Benzoyl indoles with metabolic stability as reversal agents for ABCG2-mediated multidrug resistance
Cai, Chao-Yun,Zhai, Hong,Lei, Zi-Ning,Tan, Cai-Ping,Chen, Bao-Li,Du, Zhao-Yi,Wang, Jing-Quan,Zhang, Yun-Kai,Wang, Yi-Jun,Gupta, Pranav,Wang, Bo,Chen, Zhe-Sheng
, p. 849 - 862 (2019)
Ko143, a potent ABCG2 inhibitor that reverses multidrug resistance in cancer, cannot be used clinically due to its unsuitable metabolic stability. We identified benzoyl indoles as reversal agents that reversed ABCG2-mediated multidrug resistance (MDR), wi
COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS
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Page/Page column 96, (2008/12/05)
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.
