1027787-50-3Relevant academic research and scientific papers
Benzoyl indoles with metabolic stability as reversal agents for ABCG2-mediated multidrug resistance
Cai, Chao-Yun,Zhai, Hong,Lei, Zi-Ning,Tan, Cai-Ping,Chen, Bao-Li,Du, Zhao-Yi,Wang, Jing-Quan,Zhang, Yun-Kai,Wang, Yi-Jun,Gupta, Pranav,Wang, Bo,Chen, Zhe-Sheng
, p. 849 - 862 (2019/07/12)
Ko143, a potent ABCG2 inhibitor that reverses multidrug resistance in cancer, cannot be used clinically due to its unsuitable metabolic stability. We identified benzoyl indoles as reversal agents that reversed ABCG2-mediated multidrug resistance (MDR), wi
Compound and preparation method thereof as well as application in preparation of tumor drug resistance reversal agent
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Paragraph 0042; 0043; 0044, (2018/07/06)
The invention relates to the technical field of medicines, in particular to a compound and a preparation method thereof as well as the application in preparation of a tumor drug resistance reversal agent. The invention provides a preparation method of a c
Copper-catalyzed decarboxylative C3-acylation of free (N-H) indoles with α-oxocarboxylic acids
Wang, Cuiping,Wang, Shaoyan,Li, Hua,Yan, Jingbo,Chi, Haijun,Chen, Xichao,Zhang, Zhiqiang
supporting information, p. 1721 - 1724 (2014/03/21)
An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.
A novel microwave-irradiated solvent-free 3-acylation of indoles on alumina
Lai, Qiu Yu,Liao, Rong Su,Wu, Shao Yong,Zhang, Jia Xin,Duan, Xin Hong
, p. 4069 - 4076 (2013/12/04)
A simple and efficient 3-acylation of indoles under microwave-heated and solvent-free conditions is developed. This general procedure uses neutral Al2O3 as a new, green and reusable catalyst giving good to high yields within short reaction times. Utilizing such an environmentally- benign methodology, a variety of indoles bearing electron-releasing or electron-withdrawing groups were conveniently acylated.
ZrCl4-mediated regio- and chemoselective friedel-crafts acylation of indole
Guchhait, Sankar K.,Kashyap, Maneesh,Kamble, Harshad
experimental part, p. 4753 - 4758 (2011/07/08)
An efficient method for regio- and chemoselective Friedel-Crafts acylation of indole using acyl chlorides in the presence of ZrCl4 has been discovered. It minimizes/eliminates common competing reactions that occur due to high and multiatom-nucleophilic character of indole. In this method, a wide range of aroyl, heteroaroyl alkenoyl, and alkanoyl chlorides undergo smooth acylation with various indoles without NH protection and afford 3-acylindoles in good to high yields.
COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS
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Page/Page column 95-96, (2008/12/05)
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.
