10278-39-4

Basic information

• Product Name: 2-bromo-N-(4-nitrophenyl)benzamide
• Synonyms: 2-Bromo-N-(4-nitrophenyl)benzamide; benzamide, 2-bromo-N-(4-nitrophenyl)-
• CAS NO: 10278-39-4
• Molecular Formula: C₁₃H₉BrN₂O₃
• Molecular Weight: 321.1262
• Mol File: 10278-39-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 383.3°C at 760 mmHg
• Flash Point: 185.6°C
• Density: 1.635g/cm³
• Vapor Pressure: 4.43E-06mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 2-bromo-N-(4-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(4-nitrophenyl)benzamide(10278-39-4)
• EPA Substance Registry System: 2-bromo-N-(4-nitrophenyl)benzamide(10278-39-4)

Safety Data

• Hazardous Substances Data: 10278-39-4(Hazardous Substances Data)

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 100-01-6 4-nitro-aniline 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 143805-49-6 5-(2-bromophenyl)-1-(4-nitrophenyl)-1H-tetrazole 
• 1040044-33-4 C₁₄H₁₁BrN₂O₃ 

Relevant articles and documents

Direct arylation under catalysis of an oxime-derived palladacycle: Search for a phosphane-free method

A phosphane-free method for the direct arylation of benzothiazole by employing oxime-derived palladacycle 1 as a catalyst was developed. The new catalyst system can be used for 2-arylations by using aryl bromides and iodides. In addition, this method is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well aschloroamides, to achieve a rapid synthesis of benzo[c]phenanthridine alkaloids. Direct arylation reactions under catalysis of an oxime-derived palladacycle were investigated. This phosphane-free method is applicable for the 2-arylation of benzothiazole and is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well as chloroamides, to achieve rapid synthesis of benzo[c]phenanthridine alkaloids. Copyright

Chemical process and intermediates used therein

The invention provides a novel chemical process for the manufacture of certain imidazo[4,5-b]pyridine derivatives of the formula I wherein R 1, R 2, R 3 and R 4 have the various meanings defined herein, and their non-toxic salts, which are angiotensin II inhibitors. The process involves the removal of an electron-deficient phenyl group or a pyridyl or pyrimidyl group from a compound of the formula II as defined herein. Certain of the intermediates are novel and are provided as a further feature of the invention.

PYRIDINYL COMPOUNDS WHICH ARE USEFUL AS ANGIOTENSIN II ANTAGONISTS

The invention concerns pharmaceutically useful compounds of the formula I, in which R 1, R 2, R 3, R 4, R 5, R. sup.6, R 7, Rz, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. STR1