1027804-34-7Relevant academic research and scientific papers
Access to Hetero-Benzyl Scaffolds via Transient-Ligand-Enabled Direct γ-C(sp3)-H Arylation of 3-Methylheteroarene-2-Carbaldehydes
Bhat, Ramakrishna G.,Reddy, Chennakesava,Shaikh, Javed Y.
, p. 6924 - 6934 (2020)
An efficient and straightforward method has been developed for the synthesis of β-benzyl-substituted 5-membered heterocyclic carbaldehydes via transient directing-group-enabled direct γ-C(sp3)-H arylation of 3-methylheteroarene-2-carbaldehydes. A wide range of 3-methylheteroarene carbaldehydes undergo coupling with a variety of aryl iodides, including less reactive iodo pyridine derivatives to provide a library of highly selective functionalized products in good to excellent yields. Some of these products have been successfully utilized in synthesizing useful synthetic intermediates.
Organocatalytic asymmetric reaction of indol-2-yl carbinols with enamides: Synthesis of chiral 2-indole-substituted 1,1-diarylalkanes
Liu, Chao-You,Han, Fu-She
, p. 11844 - 11847 (2015/07/15)
The chiral phosphoramide-catalyzed asymmetric reaction of indol-2-yl carbinols with enamides is presented. The method provided an efficient and novel way for the synthesis of chiral 2-indole-substituted 1,1-diarylalkane derivatives.
Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3′-diindolylarylmethanes from indol-2-yl carbinols and indoles
Qi, Shuai,Liu, Chao-You,Ding, Jin-Ying,Han, Fu-She
supporting information, p. 8605 - 8608 (2014/07/22)
We present the first asymmetric reaction of indol-2-yl carbinols with indole derivatives catalyzed by chiral phosphoramides for the enantioselective synthesis of 2,3′-diindolylarylmethanes in excellent yields of over 90% as well as high enantioselectivity
