1027957-62-5

Basic information

• Product Name: N²-(7-Fluoro-quinolin-4-yl)-propane-1,2-diamine
• Synonyms: N²-(7-Fluoro-quinolin-4-yl)-propane-1,2-diamine
• CAS NO: 1027957-62-5
• Molecular Weight: 219.262
• Mol File: 1027957-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N²-(7-Fluoro-quinolin-4-yl)-propane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(7-Fluoro-quinolin-4-yl)-propane-1,2-diamine(1027957-62-5)
• EPA Substance Registry System: N²-(7-Fluoro-quinolin-4-yl)-propane-1,2-diamine(1027957-62-5)

Safety Data

• Hazardous Substances Data: 1027957-62-5(Hazardous Substances Data)

Upstream product

• 391-82-2 4-Chloro-7-fluoroquinoline 
• 78-90-0 1,2-diaminopropan 

Relevant articles and documents

Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines

Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).