391-82-2

Basic information

• Product Name: 4-CHLORO-7-FLUOROQUINOLINE
• Synonyms: 4-CHLORO-7-FLUOROQUINOLINE
• CAS NO: 391-82-2
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.59
• Mol File: 391-82-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 73.5-74 °C
• Boiling Point: 259.9°C at 760 mmHg
• Flash Point: 111°C
• Appearance: /
• Density: 1.366g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 2.38±0.27(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-FLUOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-FLUOROQUINOLINE(391-82-2)
• EPA Substance Registry System: 4-CHLORO-7-FLUOROQUINOLINE(391-82-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• Hazardous Substances Data: 391-82-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-7-fluoroquinoline is a chemical compound with the molecular formula C9H5ClFN. It is a quinoline derivative that contains both chlorine and fluorine atoms. 4-CHLORO-7-FLUOROQUINOLINE is often used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It exhibits antimicrobial and antibacterial properties, making it a valuable ingredient in the development of new drugs and treatments. Additionally, it is also used in research and development activities in the field of medicinal chemistry. Due to its unique structure and reactivity, 4-chloro-7-fluoroquinoline is a significant and versatile chemical compound with numerous potential applications.

InChI:InChI=1/C9H5ClFN/c10-8-3-4-12-9-5-6(11)1-2-7(8)9/h1-5H

Upstream product

• 391-83-3 7-fluoro-4-hydroxyquinoline 
• 86-98-6 4,7-dichloroquinoline 
• 26892-97-7 7-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester 
• 183057-56-9 7-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 26892-97-7 ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate 
• 63463-20-7 7-Fluoro-4-hydroxyquinoline-3-carboxylic acid 
• 26832-95-1 diethyl 2-(((3-fluorophenyl)amino)methylene)malonate 
• 372-19-0 meta-fluoroaniline 
• 391-83-3 7-fluoro-1,4-dihydroquinolin-4-one 

Downstream Products

• 442-96-6 rac-N¹,N¹-diethyl-N⁴-(7-fluoroquinolin-4-yl)pentane-1,4-diamine 

Relevant articles and documents

19F NMR spectroscopy of polyhalonaphthalenes. Part IV. Halex reactions of polychloroquinolines

Nucleophilic fluoride dechlorination of four starting materials (5,6,7,8-tetrachloro-, 3,5,6,7,8-pentachloro-, 4,7-dichloro-, 2,3,4,5,6,7,8-heptachloro-quinoline) led to the preparation of thirteen new polychloropolyfluoroquinolines via reaction with caesium fluoride in DMSO at 100°C. The product from the perchloroquinoline was an inseparable mixture of C9Cl7_nF.nN where n is 1-3. These products were studied in the NMR tube.

PHOSPHONATE-CHLOROQUINE CONJUGATES AND METHODS USING SAME

The present invention provides compositions and methods for providing controllable local delivery of a conjugate of chloroquine (CQ) and a bisphosphonate to treat diseases characterized by abnormal bone metabolism. In certain embodiments, the invention is used as a treatment for a subject with diseases and disorders characterized by bone loss.

QUINOLINE DERIVATIVES

The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.